Results 41 to 50 of about 40,345 (282)

HIV-1 Proviral Transcription and Latency in the New Era

Viruses, 2020
Three decades of extensive work in the HIV field have revealed key viral and host cell factors controlling proviral transcription. Various models of transcriptional regulation have emerged based on the collective information from in vitro assays and work
Ashutosh Shukla, Nora-Guadalupe P. Ramirez, Iván D’Orso   +2 more
doaj   +1 more source

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells [PDF]

Cell, 2015
Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen.
Bin Yang, C. E. Farran, H. Guo, Tao Yu, H. Fang, Hao Fei Wang, Sharon Schlesinger, Yu Fen Samantha Seah, Germaine Goh, S. P. Neo, Yinghui Li, M. Lorincz, V. Tergaonkar, T. Lim, Lingyi Chen, J. Gunaratne, J. Collins, S. Goff, G. Daley, Hu Li, F. Bard, Y. Loh   +21 more
semanticscholar   +6 more sources

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

Cellular and Molecular Life Sciences, 2019
35 years since identification of HIV as the causative agent of AIDS, and 35 million deaths associated with this disease, significant effort is now directed towards the development of potential cures.
I. Sadowski, F. Hashemi
semanticscholar   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Activation of an oncogenic microRNA cistron by provirus integration [PDF]

Proceedings of the National Academy of Sciences, 2006
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron.
Lauri Li, Bruce Wang, Namitha Channa, Clifford L. Wang, Gabor Bartha, Matthias Wabl, Nigel Killeen, Mark Klinger   +7 more
openaire   +3 more sources

Clinical Aspects of Feline Retroviruses: A Review [PDF]

, 2012
Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease.
Ackley, Anderson, Barlough, Barnett, Barr, Beatty, Beatty, Beatty, Bishop, Bishop, Brightman, Brown, Callanan, Callanan, Carmichael, Choi, Cotter, Cotter, Cotter, Court, Cullen, Day, Dean, Diehl, Dow, Ellis, English, Essex, Fleming, Flynn, Francis, Garg, Gunn-Moore, Hara, Hardy, Harrus, Heit, Hoffmann-Fezer, Hofmann-Lehmann, Holznagel, Hoover, Hoover, Hutson, Jackson, Jarrett, Johnson, Joshi, Katrin Hartmann, Kipar, Kohn, Kubes, Lauring, Levy, Levy, Levy, Liang, Linenberger, Lott-Stolz, Matsumoto, Mitchell, Mizuno, Mizuno, Mizuno, Mortola, Mortola, Novotney, O'Connor, Ohno, Ohno, Overbaugh, Pedersen, Pedersen, Phillips, Phipps, Podell, Podell, Pool, Power, Prospero-Garcia, Quackenbush, Reinacher, Rickard, Ritchey, Rohn, Schrenzel, Sellon, Sellon, Sheets, Shelton, Shelton, Shimojima, Shimojima, Stiles, Taniguchi, Tompkins, Torten, Tsatsanis, Willett, Willett, Zaccaro, Zhao   +100 more
core   +3 more sources

Targeting Epigenetics to Cure HIV-1: Lessons From (and for) Cancer Treatment

Frontiers in Cellular and Infection Microbiology, 2021
The Human Immunodeficiency Virus type 1 (HIV-1) integrates in the host genome as a provirus resulting in a long-lived reservoir of infected CD4 cells. As a provirus, HIV-1 has several aspects in common with an oncogene.
J. Peter Svensson
doaj   +1 more source

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

Frontiers in Microbiology, 2019
Background HIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common.
Andrew Musick, J. Spindler, E. Boritz, L. Pérez, Daniel Crespo-Vélez, S. Patro, M. Sobolewski, Michael J. Bale, C. Reid, B. Keele, A. Capoferri, W. Shao, A. Wiegand, F. Simonetti, J. Mellors, S. Hughes, J. Coffin, F. Maldarelli, Mary F. Kearney   +18 more
semanticscholar   +1 more source

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy [PDF]

, 1999
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load.
Bangham, C.R.M., Bunce, M., Hall, S.E., Izumo, S., Jeffery, K.J.M., Kodama, D., Lloyd, A.L., Matsumoto, W., Nagai, M., Nowak, M.A., Ogg, G.S., Osame, M., Procter, J., Taylor, G.P., Usuku, K., Weber, J.N., Welsh, K.I.   +16 more
core   +2 more sources

Precise excision of HTLV-1 provirus with a designer-recombinase

Molecular Therapy, 2023
The human T cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that persists as a provirus in the genome of infected cells and can lead to adult T cell leukemia (ATL). Worldwide, more than 10 million people are infected and approximately 5% of these individuals will develop ATL, a highly aggressive cancer that is currently incurable. In the
Teresa Rojo-Romanos, Janet Karpinski, Sebastian Millen, Niklas Beschorner, Florian Simon, Maciej Paszkowski-Rogacz, Felix Lansing, Paul Martin Schneider, Jan Sonntag, Joachim Hauber, Andrea K. Thoma-Kress, Frank Buchholz   +11 more
openaire   +2 more sources