Results 51 to 60 of about 66,750 (285)

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

Scientific Reports, 2023
Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter.
Riley M. Horvath, Zabrina L. Brumme, Ivan Sadowski   +2 more
doaj   +1 more source

Genome editing technologies to fight infectious diseases [PDF]

, 2017
Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa, Pal\ue3\ub9, Giorgio, Trevisan, Marta   +2 more
core   +1 more source

Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

Infectious Agents and Cancer, 2020
The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people.
Mark H. Kaplan, Rafael Contreras-Galindo, Evelyn Jiagge, Sofia D. Merajver, Lisa Newman, Galya Bigman, Michael H. Dosik, Ganesh S. Palapattu, Javed Siddiqui, Arul M. Chinnaiyan, Sally Adebamowo, Clement Adebamowo   +11 more
doaj   +1 more source

The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]

, 2015
Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M, Campo-Fernandez, Beatriz, Cooper, Aaron R, Hoban, Megan D, Hollis, Roger P, Kaufman, Michael L, Kohn, Donald B, Lumaquin, Dianne, Romero, Zulema, Senadheera, Shantha, Urbinati, Fabrizia, Wang, Xiaoyan, Wherley, Jennifer   +12 more
core   +4 more sources

5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals

Retrovirology, 2006
We previously described selective hypermethylation of the 5'-long terminal repeat (LTR) of HTLV-1 provirus in vivo and in vitro. This prompted us to analyze CpG methylation of the two LTRs of the HIV provirus in chronically infected cell lines.
Watanabe Toshiki, Koiwa Tsukasa, Hamano Akiko, Ishida Takaomi   +3 more
doaj   +1 more source

HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs

Virulence, 2022
HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu that accompanies viral production is ...
Albebson L. Lim, Philip Moos, Christopher D. Pond, Erica C. Larson, Laura J. Martins, Matthew A. Szaniawski, Vicente Planelles, Louis R. Barrows   +7 more
doaj   +1 more source

Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses
The field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
doaj   +1 more source

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
doaj   +1 more source

CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus

Frontiers in Microbiology, 2018
HIV-1 infection can be successfully controlled with anti-retroviral therapy (ART), but is not cured. A reservoir of cells harboring transcriptionally silent integrated provirus is able to reestablish replicating infection if ART is stopped.
A. Panfil, James A. London, P. Green, K. Yoder   +3 more
semanticscholar   +1 more source

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART. [PDF]

, 2014
Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated.
Adamson, Lourdes, Cannavo, Elda, Deere, Jesse D, Higgins, Joanne, Kauffman, Robert C, Luciw, Paul A, North, Thomas W, Schinazi, Raymond F, Villalobos, Andradi   +8 more
core   +5 more sources