Results 51 to 60 of about 40,345 (282)

Targeting and Understanding HIV Latency: The CRISPR System against the Provirus [PDF]

Pathogens, 2021
The presence of latently infected cells and reservoirs in HIV-1 infected patients constitutes a significant obstacle to achieve a definitive cure. Despite the efforts dedicated to solve these issues, the mechanisms underlying viral latency are still under study. Thus, on the one hand, new strategies are needed to elucidate which factors are involved in
Magro G., Calistri A., Parolin C.
openaire   +4 more sources

Viral Reservoirs in Lymph Nodes of FIV-Infected Progressor and Long-Term Non-Progressor Cats during the Asymptomatic Phase. [PDF]

, 2016
BackgroundExamination of a cohort of cats experimentally infected with feline immunodeficiency virus (FIV) for 5.75 years revealed detectable proviral DNA in peripheral blood mononuclear cells (PBMCs) harvested during the asymptomatic phase, undetectable
Eckstrand, CD, Hillman, C, Murphy, BG, Smith, AL, Sparger, EE   +4 more
core   +5 more sources

Quantitative analysis of CRISPR/Cas9-mediated provirus deletion in blue egg layer chicken PGCs by digital PCR

Scientific Reports, 2022
Primordial germ cells (PGCs), the precursors of sperm and oocytes, pass on the genetic material to the next generation. The previously established culture system of chicken PGCs holds many possibilities for functional genomics studies and the rapid ...
Stefanie Altgilbers, Claudia Dierks, Sabine Klein, Steffen Weigend, Wilfried A. Kues   +4 more
doaj   +1 more source

HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus

Scientific Reports, 2019
Regardless of recent advances in the development of anti-retroviral drugs, it is still extremely difficult to eradicate HIV-1 from infected individuals. The characterization of the HIV-1 provirus, a type of viral reservoir, with a high resolution is key ...
Saori C. Iwase, P. Miyazato, H. Katsuya, S. Islam, B. Yang, Jumpei Ito, M. Matsuo, H. Takeuchi, T. Ishida, K. Matsuda, K. Maeda, Yorifumi Satou   +11 more
semanticscholar   +1 more source

Disruption or Excision of Provirus as an Approach to HIV Cure [PDF]

AIDS Patient Care and STDs, 2016
An effective approach to HIV cure will almost certainly require a combination of strategies, including some means of reducing the latent HIV reservoir. Because the integrated HIV provirus represents the major source of viral persistence and reactivation, one attractive approach is the direct targeting of provirus for disruption or excision using ...
openaire   +3 more sources

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors [PDF]

, 2017
Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction.
Bieniasz, Paul D., Blanco-Melo, Daniel, Gifford, Robert J.   +2 more
core   +2 more sources

Domestic chickens activate a piRNA defense against avian leukosis virus [PDF]

, 2017
PIWI-interacting RNAs (piRNAs) protect the germ line by targeting transposable elements (TEs) through the base-pair complementarity. We do not know how piRNAs co-evolve with TEs in chickens.
Anai, Aravin, Aravin, Aravin, Assis, Baluda, Bao, Bartel, Benkel, Bolisetty, Boyce-Jacino, Boyce-Jacino, Brawand, Brennecke, Carmell, Cenik, Cenik, Chen, Chirn, Crittenden, Dempster, Eickbush, Eriksson, Fadly, Fagegaltier, Farazi, Feschotte, Flemr, Frisby, Frost, Gao, Ghildiyal, Gifford, Goic, Gunawardane, Guo, Haas, Han, Hayward, Houwing, Houwing, Ingolia, Ingolia, International Chicken Genome Sequencing Consortium, Johnson, Jurka, Ka, Ka, Khurana, Kim, Kohany, Kojima, Kuhnlein, Kumar, Kumar, Kuramochi-Miyagawa, Kuramochi-Miyagawa, Lee, Levin, Lewinski, Li, Li, Li, Lim, Lin, Lu, Malik, Malone, McClintock, Meunier, Moore, Nawrocki, Necsulea, Oh, Paradis, Peirson, Pelechano, Reuter, Reuter, Ricci, Roberts, Robinson, Rosenkranz, Rutherford, Sacco, Saxe, Schlötterer, Shoji, Smit, Smith, Smith, Smith, Smith, Soper, Stehelin, Steitz, Stoye, Sumiyoshi, Tam, Tanaka, Tarlinton, Team, Temin, Tereba, Thompson, Thomson, Trapnell, Trapnell, Vandergon, Varmus, Wang, Wang, Watanabe, Weiss, Weiss, Weiss, West, Wichert, Wicker, Wilson, Yabuta, Zhang, Zhang, Zheng, Zhuang   +124 more
core   +2 more sources

Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

Infectious Agents and Cancer, 2020
The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people.
Mark H. Kaplan, Rafael Contreras-Galindo, Evelyn Jiagge, Sofia D. Merajver, Lisa Newman, Galya Bigman, Michael H. Dosik, Ganesh S. Palapattu, Javed Siddiqui, Arul M. Chinnaiyan, Sally Adebamowo, Clement Adebamowo   +11 more
doaj   +1 more source

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

Scientific Reports, 2023
Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter.
Riley M. Horvath, Zabrina L. Brumme, Ivan Sadowski   +2 more
doaj   +1 more source

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. [PDF]

, 2019
BackgroundHIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms
Aran, Dvir, Butte, Atul J, Greene, Warner C, Hsieh, Christine, Joshi, Sunil, Kim, Peggy, Montano, Mauricio, Morón-López, Sara, Telwatte, Sushama, Wong, Joseph K, Yukl, Steven A   +10 more
core   +1 more source