Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]
, 2020 The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle +16 more
core +1 more source
Rapid and sensitive insulated isothermal PCR for point-of-need feline leukaemia virus detection [PDF]
, 2017 Objectives: Feline leukaemia virus (FeLV), a gamma retrovirus, causes diseases of the feline haematopoietic system that are invariably fatal. Rapid and accurate testing at the point-of-need (PON) supports prevention of virus spread and management of ...
Anis, Eman +8 more
core +1 more source
Wellcome Open Research, 2018 Background: The human retrovirus HTLV-1 inserts the viral complementary DNA of 9 kb into the host genome. Both plus- and minus-strands of the provirus are transcribed, respectively from the 5′ and 3′ long terminal repeats (LTR). Plus-strand expression is
Michi Miura +4 more
doaj +1 more source
Quantification of unintegrated HIV-1 DNA at the single cell level in vivo. [PDF]
PLoS ONE, 2012 In the nucleus of HIV-1 infected cells, unintegrated HIV-1 DNA molecules exist in the form of one and two LTR circles and linear molecules with degraded extremities.
Rodolphe Suspène, Andreas Meyerhans
doaj +1 more source
Retrovirology, 2018 Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to ...
M. Montesion +4 more
semanticscholar +1 more source
Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms
Retrovirology, 2005 Background Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) after a long latent period. Among accessory genes encoded by HTLV-I, the tax gene is thought to play a central role in oncogenesis.
Mueller Nancy +6 more
doaj +1 more source
HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin
Scientific Reports, 2016 HIV-1 Vpr is an accessory protein that induces proteasomal degradation of multiple proteins. We recently showed that Vpr targets class I HDACs on chromatin for proteasomal degradation. Here we show that Vpr induces degradation of HDAC1 and HDAC3 in HIV-1
Bizhan Romani +6 more
semanticscholar +1 more source
Transcriptional provirus silencing in the context of the integration site environment [PDF]
Retrovirology, 2013 Background Autonomous transcription of integrated retroviruses strongly depends on the genetic and epigenetic effects exerted by chromatin at the site of integration. These effects are mostly suppressive and proviral transcription can be ultimately silenced by mechanisms such as DNA methylation and histone modifications.
Jiří Hejnar +3 more
openaire +2 more sources
Baboon endogenous virus genome: Molecular cloning and structural characterization of nondefective viral genomes from DNA of a baboon cell strain [PDF]
, 1981 Several heterogeneities in the baboon endogenous virus (BaEV) genomes that are present in the DNA of normal baboon tissues and the baboon cell strain BEF-3 have been described previously.
Cohen, Maurice +8 more
core +1 more source
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]
, 2020 Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim +7 more
core +2 more sources