CpG Methylation Profiles of HIV-1 Proviral DNA in Individuals on ART
Viruses, 2021 The latent HIV-1 reservoir is comprised of stably integrated and intact proviruses with limited to no viral transcription. It has been proposed that latent infection may be maintained by methylation of pro-viral DNA.
Valerie F. Boltz +11 more
doaj +1 more source
Differential disease restriction of Moloney and Friend murine leukemia viruses by the mouse Rmcf gene is governed by the viral long terminal repeat. [PDF]
, 1991 Neonatal CxD2 (Rmcfr) and Balb/c (Rmcfs) mice inoculated with Moloney murine leukemia virus (M-MuLV) exhibited approximately equivalent time course and pathology for disease.
Brightman, BK, Fan, H, Li, QX, Trepp, DJ
core
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis
eLife, 2018 Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the structure
Anat Melamed +6 more
doaj +1 more source
Highly Efficient Gene Expression in B Lymphocytes Mediating by Lentivirus Vector [PDF]
, 2012 Gene transduction and expression efficiencies among several type cell lines were compared by using vesicular stomatitis virus-glycoprotein (VSV-G) pseudotyped human immunodeficiency virus type-1 (HIV-1) based lentivirus vector. Large discrepancies of the
Akira Tempaku
core +1 more source
Feline blood donation via cephalic intravenous catheter: A novel method
Veterinary Record, EarlyView.Abstract Background Feline jugular blood donation requires heavy sedation or a very compliant cat. Donation using an intravenous catheter requires less restraint and potentially decreases stress. Methods This was an observational study of feline blood donors at a veterinary hospital between February and June 2023.
Charlotte Russo, Karen Humm
wiley +1 more source
HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin
Scientific Reports, 2016 HIV-1 Vpr is an accessory protein that induces proteasomal degradation of multiple proteins. We recently showed that Vpr targets class I HDACs on chromatin for proteasomal degradation. Here we show that Vpr induces degradation of HDAC1 and HDAC3 in HIV-1
Bizhan Romani +6 more
semanticscholar +1 more source
Microbiology and Immunology, EarlyView.ABSTRACT Bovine leukemia virus (BLV) is widespread globally and causes economic losses in the cattle industry. Shandong Province plays a significant role in China's livestock industry, with an increasing importance in food of Holstein and Angus cattle. However, BLV prevalence in Holstein and Angus breeds in Shandong Province remains unclear.
Jingyuan Wang +13 more
wiley +1 more source
LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]
, 2010 Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA +5 more
core +3 more sources
Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. [PDF]
, 2020 Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo.
Chang, Deching +13 more
core +2 more sources