From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley +1 more source
Relevance of the variability of the feline immunodeficiency virus in regard to pathogenicity and vaccination in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science, Massey University, Manawatū, New Zealand [PDF]
Cats infected with the feline immunodeficiency virus (FIV) show a range of clinical signs. Given the variability of the FIV genome, it is possible that there is variation in certain biological characteristics of FIV, such as pathogenicity.
Stickney, Alison Louise
core
No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms [PDF]
Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic ...
Burmeister, Thomas +4 more
core +2 more sources
Fossil record of an archaeal HK97-like provirus
One of the outstanding questions in biology today is the origin of viruses. We have discovered a protein in the hyperthermophile Sulfolobus solfataricus while following proteome regulation during viral infection that led to the discovery of a fossil provirus.
Heinemann, Joshua +8 more
openaire +2 more sources
Is the innate bio-protection power against human virus the same between males and females? A conclusion based on blood donor data of HTLV-I infection [PDF]
Human T-cell leukemia virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukemia. The male-to-female transmission is stronger than the reverse, so the carrier proportion of women is greater than that of men.
Minoru Tabata +3 more
core +1 more source
Understanding the mechanisms of HIV proviral latency is essential for development of a means to eradicate infection and achieve a cure. We have previously described an in vitro latency model that reliably identifies HIV expression phenotypes of infected ...
F. Hashemi +5 more
semanticscholar +1 more source
This study identified DNA viruses from Qiangyong proglacial lake sediments on the Tibetan Plateau, revealing a highly diverse and previously uncharacterized viral community. These viruses influence microbial community structure and function by infecting key nutrient‐transforming taxa and encoding auxiliary metabolic genes that modulate host metabolism.
Yang Zhao +6 more
wiley +1 more source
Prevalence of feline leukaemia provirus DNA in feline lymphomas
A significant drop in the prevalence of feline leukaemia virus (FeLV) antigenaemic cats and antigen-associated lymphomas has been observed after the introduction of FeLV vaccination and antigen-testing with removal of persistently antigenaemic cats. However, recent reports have indicated that regressively infected cats may contain FeLV provirus DNA ...
Garrick M Moll +2 more
openaire +4 more sources
Prevalence of Different Courses of Feline Leukaemia Virus Infection in Four European Countries
Prevalence of progressive feline leukaemia virus (FeLV) infection is known to still be high in cats in Europe, especially in Southern Europe, but the prevalence of other outcomes of FeLV infection has not been determined in most countries.
Juliana Giselbrecht +13 more
doaj +1 more source
Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors [PDF]
Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction.
Bieniasz, Paul D. +2 more
core +2 more sources

