Results 11 to 20 of about 18,625 (239)
Intragenic proviral elements support transcription of defective HIV-1 proviruses. [PDF]
PLoS Pathogens, 2021 HIV-1 establishes a persistent proviral reservoir by integrating into the genome of infected host cells. Current antiretroviral treatments do not target this persistent population of proviruses which include latently infected cells that upon treatment ...
Jeffrey Kuniholm +10 more
doaj +5 more sources
Defective HIV-1 proviruses produce viral proteins [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance In HIV-infected patients on combination antiretroviral therapy (cART), greater than 95% of proviruses in the peripheral blood are “defective.” Historically, these defective proviruses have been thought to be dead-end products with no real ...
H. Imamichi +11 more
semanticscholar +3 more sources
A systematic analysis of marine lysogens and proviruses
Nature Communications, 2023 Viruses are ubiquitous in the oceans, exhibiting high abundance and diversity. Here, we systematically analyze existing genomic sequences of marine prokaryotes to compile a Marine Prokaryotic Genome Dataset (MPGD, consisting of over 12,000 bacterial and ...
Yi Yi +14 more
semanticscholar +4 more sources
On the generation of the MSD-Ѱ class of defective HIV proviruses [PDF]
Retrovirology, 2019 Antiretroviral therapy (ART) can effectively suppress ongoing HIV replication and block disease progression, but the infection is never cured due to the persistence of a small pool of latently infected cells hosting integrated replication-competent HIV ...
Atze T. Das +2 more
doaj +5 more sources
The Journal of Clinical Investigation, 2023 Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4+ T cell clones ...
Jennifer A. White +29 more
doaj +2 more sources
Defective proviruses rapidly accumulate during acute HIV-1 infection [PDF]
Nature Medicine, 2016 Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form that is not targeted by the immune system or by ART.
Katherine M. Bruner +14 more
semanticscholar +5 more sources
Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John +13 more
core +2 more sources
Cell Reports, 2017 Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to determine the distribution of latent replication-competent HIV-1 within ...
Bonnie Hiener +18 more
doaj +2 more sources
Viruses, 2018 Individual groups of retroviruses and retroviral vectors differ in their integration site preference and interaction with the host genome. Hence, immediately after infection genome-wide distribution of integrated proviruses is non-random.
Dalibor Miklík +2 more
doaj +2 more sources
Journal of Virus Eradication, 2017 Background: HIV-1 infection remains incurable on antiretroviral therapy (ART) due to virus latency. To date, enhanced co-culture assays, including viral outgrowth assays (VOA), are commonly used to measure HIV-1 latent reservoirs and evaluate latency ...
Zhe Yuan +3 more
doaj +2 more sources