Results 31 to 40 of about 13,226 (233)

The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time

Research Square, 2023
Within-host HIV populations continually diversify during untreated infection, and this diversity persists within infected cell reservoirs during antiretroviral therapy (ART).
A. Shahid, Signe MacLennan, B. Jones, H. Sudderuddin, Zhong Dang, K. Cobarrubias, M. Duncan, N. Kinloch, M. J. Dapp, N. Archin, M. Fischl, I. Ofotokun, A. Adimora, S. Gange, B. Aouizerat, M. Kuniholm, Seble G. Kassaye, J. Mullins, H. Goldstein, J. Joy, K. Anastos, Z. Brumme   +21 more
semanticscholar   +1 more source

Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods.

PLoS Pathogens, 2022
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier to cure.
Jennifer A White, Joshua T Kufera, Niklas Bachmann, Weiwei Dai, Francesco R Simonetti, Ciara Armstrong, Jun Lai, Subul Beg, Janet D Siliciano, Robert F Siliciano   +9 more
doaj   +1 more source

Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections

Viruses, 2020
Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection; HIV persistence is the principal obstacle to curing infections.
Elizabeth M. Anderson, Francesco R. Simonetti, Robert J. Gorelick, Shawn Hill, Monica A. Gouzoulis, Jennifer Bell, Catherine Rehm, Liliana Pérez, Eli Boritz, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Venigalla Rao, John M. Coffin, Mary F. Kearney, Frank Maldarelli   +15 more
doaj   +1 more source

Impact of BoLA-DRB3 Polymorphisms on Clonality of Bovine Leukaemia Virus-Infected Cells of Cattle With Lymphoma. [PDF]

HLA
ABSTRACT Bovine leukaemia virus (BLV) infects cattle, integrates into the host genome as a provirus, and induces a persistent infection that remains asymptomatic but can cause leukaemia/lymphoma. Most BLV‐infected cell clones are created by massive depletion, and a few of these infected cell clones expand through the mitotic cycle, leading to the onset
Fukushi N, Yamanaka MP, Matsuura R, Watanuki S, Saito S, Matsumoto Y, Fukumoto K, Hosomichi K, Wang J, Takeshima SN, Aida Y.   +10 more
europepmc   +2 more sources

Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance In persons living with HIV-1 who start antiretroviral therapy, virus in the blood decreases rapidly to below the detection limit. The decrease occurs in two phases: a rapid initial decrease in the first weeks, followed by a second, slower ...
J. White, F. Simonetti, Subul A. Beg, Natalie F. McMyn, W. Dai, N. Bachmann, J. Lai, William C Ford, Christina Bunch, Joyce L. Jones, R. Ribeiro, A. Perelson, J. Siliciano, R. Siliciano   +13 more
semanticscholar   +1 more source

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Microbiology Spectrum, 2023
In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission.
Pauline Trémeaux, Frédéric Lemoine, Adeline Mélard, Marine Gousset, Faroudy Boufassa, Sylvie Orr, Valérie Monceaux, Olivier Gascuel, Olivier Lambotte, Laurent Hocqueloux, Asier Saez-Cirion, Christine Rouzioux, Véronique Avettand-Fenoel   +12 more
doaj   +1 more source

Varied Interactions Between Proviruses and Adjacent Host Chromatin [PDF]

Molecular and Cellular Biology, 1986
Retroviruses integrated at unique locations in the host genome can be expressed at different levels. We have analyzed the preintegration sites of three transcriptionally competent avian endogenous proviruses (evs) to determine whether the various levels of provirus expression correlate with their location in active or inactive regions of chromatin. Our
K F, Conklin, M, Groudine
openaire   +4 more sources

Human endogenous retrovirus-K mRNA expression and genomic alignment data in hepatoblastoma

Data in Brief, 2020
Human Endogenous Retroviruses are a class of genomic elements that are the result of ancient retroviral infection of the human germline. Many are biologically active elements that have been implicated in multiple diseases including cancer.
David F Grabski, Aakrosh Ratan, Laurie R Gray, Stefan Bekiranov, David Rekosh, Marie-Louise Hammarskjold, Sara K Rasmussen   +6 more
doaj   +1 more source

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

Annals of Neurology, 2022
Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease.
Catherine R. Cochrane, T. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C Guanizo, Gemma S Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J Gartner, T. Jenkins, P. Gorry, B. Brew, S. Lewin, J. Estes, Michael Roche, M. Churchill   +18 more
semanticscholar   +1 more source

Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues.

PLoS Biology, 2022
Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in cancers, yet their activity in nondiseased tissue is largely unknown.
Aidan Burn, Farrah Roy, Michael Freeman, John M Coffin   +3 more
doaj   +2 more sources