Results 31 to 40 of about 18,625 (239)

Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues.

PLoS Biology, 2022
Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in cancers, yet their activity in nondiseased tissue is largely unknown.
Aidan Burn, Farrah Roy, Michael Freeman, John M Coffin   +3 more
doaj   +2 more sources

Human endogenous retrovirus-K mRNA expression and genomic alignment data in hepatoblastoma

Data in Brief, 2020
Human Endogenous Retroviruses are a class of genomic elements that are the result of ancient retroviral infection of the human germline. Many are biologically active elements that have been implicated in multiple diseases including cancer.
David F Grabski, Aakrosh Ratan, Laurie R Gray, Stefan Bekiranov, David Rekosh, Marie-Louise Hammarskjold, Sara K Rasmussen   +6 more
doaj   +1 more source

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed, Chavez, Leonard, Chew, Glen M, Danesh, Ali, Deeks, Steven G, Deng, Xutao, Hirashima, Mitsuomi, Hoh, Rebecca, Keating, Sheila, Lanteri, Marion, Ndhlovu, Lishomwa C, Niki, Toshiro, Norris, Philip J, Pillai, Satish K, Sacha, Jonah B, Samuels, Michael L, Shikuma, Cecilia M, Tandon, Ravi   +17 more
core   +8 more sources

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Microbiology Spectrum, 2023
In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission.
Pauline Trémeaux, Frédéric Lemoine, Adeline Mélard, Marine Gousset, Faroudy Boufassa, Sylvie Orr, Valérie Monceaux, Olivier Gascuel, Olivier Lambotte, Laurent Hocqueloux, Asier Saez-Cirion, Christine Rouzioux, Véronique Avettand-Fenoel   +12 more
doaj   +1 more source

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

bioRxiv, 2022
Antiretroviral therapy controls but does not cure HIV-1 infection due to a reservoir of rare CD4+ T cells harboring latent proviruses. To date little is known about the transcriptional program of latent cells. Here we report on a novel strategy to enrich
G. Weymar, Y. Bar-On, Thiago Y. Oliveira, C. Gaebler, Victor Ramos, Harald Hartweger, Gaëlle Breton, M. Caskey, Lillian B. Cohn, M. Jankovic, M. Nussenzweig   +10 more
semanticscholar   +1 more source

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. [PDF]

, 2020
Despite reductions in mortality from the use of highly active antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents HIV cure/eradication.
Bukrinsky, Michael, Dubrovsky, Larisa, Jada, Tejaswi, Ochem, Alex, Sahu, Geetaram, Sharma, Adhikarimayum Lakhikumar, Simon, Gary, Sun, Lin, Tyagi, Mudit, Yue, Han, Zicari, Sonia   +10 more
core   +2 more sources

A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Nature, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1–3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Katherine M. Bruner, Z. Wang, F. Simonetti, A. Bender, K. J. Kwon, Srona Sengupta, Emily J. Fray, Subul A. Beg, A. Antar, K. Jenike, L. Bertagnolli, A. Capoferri, J. Kufera, Andrew E Timmons, C. Nobles, J. Gregg, N. Wada, Y. Ho, Hao Zhang, J. Margolick, J. Blankson, S. Deeks, F. Bushman, J. Siliciano, G. Laird, R. Siliciano   +25 more
semanticscholar   +1 more source

Droplet microfluidic sequencing of HIV proviruses with their integration sites in patients receiving antiretroviral therapy

Nature Biomedical Engineering, 2022
The human immunodeficiency virus (HIV) integrates its genome into that of infected cells and may enter an inactive state of reversible latency that cannot be targeted using antiretroviral therapy.
Chen Sun, Leqian Liu, L. Pérez, Xiangpeng Li, Yifan Liu, Peng Xu, E. Boritz, J. Mullins, A. Abate   +8 more
semanticscholar   +1 more source

Baboon endogenous virus genome: Molecular cloning and structural characterization of nondefective viral genomes from DNA of a baboon cell strain [PDF]

, 1981
Several heterogeneities in the baboon endogenous virus (BaEV) genomes that are present in the DNA of normal baboon tissues and the baboon cell strain BEF-3 have been described previously.
Cohen, Maurice, Davidson, Norman, Gilden, Raymond V., McAllister, Robert M., Nicolson, Margery O., O'Connell, Catherine, Rein, Alan, Shure, Mavis, Stephens, Robert M.   +8 more
core   +1 more source

HIV-1 reservoir evolution in infants infected with clade C from Mozambique

International Journal of Infectious Diseases, 2023
Background: The persistence of HIV-1-infected cells during antiretroviral therapy is well documented but may be modulated by early initiation of antiretroviral therapy in infants.
Catherine K. Koofhethile, Stefano Rinaldi, Yelizaveta Rassadkina, Vinh B. Dinh, Ce Gao, Suresh Pallikkuth, Pilar Garcia-Broncano, Lesley R. de Armas, Rajendra Pahwa, Nicola Cotugno, Paula Vaz, Maria Grazia Lain, Paolo Palma, Xu G. Yu, Roger Shapiro, Savita Pahwa, Mathias Lichterfeld   +16 more
doaj   +1 more source