Results 121 to 130 of about 1,043,240 (311)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Strengthening Trade Adjustment Assistance [PDF]
More than 40 years ago, Congress established the Trade Adjustment Assistance (TAA) program to provide assistance to workers and firms adversely affected by import competition.
Howard F. Rosen
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Life Insurance and its Provision of In-build Security
COMMERCE TODAY, 2018 The urge for protection led to the invention of insurance. Life insurance policies are the instruments of social security for the welfare of individuals. In today’s uncertain world it has earned paramount importance and is one of the basic necessity of life.
openaire +1 more source
Analisis Biaya dan Produktivitas Pemakaian Alat Berat pada Kegiatan Pembangunan Jalan Akses Siak IV Pekanbaru [PDF]
, 2018 Road construction requires heavy equipment in its work, one of them is road layer. Heavy equipments which currently use is dump truck, excavator, motor greder, water tank truck, tandem roller and wheel loader.
Djuniati, S. (Sri) +2 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Recent Trends in the Argumentation of the European Court of Human Rights on Children’s Rights
Public Governance, Administration and Finances Law ReviewThe European Convention on Human Rights (ECHR) is a key human rights treaty ratified by all EU member states and beyond. Although it does not focus specifically on children, it includes relevant provisions and obliges states to protect the rights of all ...
Ágnes Lux
doaj +1 more source
Retirement Policies, Employment, and Unemployment [PDF]
, 1979 [Excerpt] There is a growing consensus among economists that reliance on aggregate demand policies alone will not be sufficient to move the economy to full employment with a nonaccelerating inflation rate, and that policies which alter the structure of ...
Ehrenberg, Ronald G
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source