Results 71 to 80 of about 78,202 (311)

Dutch protocol from Groningen (the so-called Groningen Protocol). The problem of deliberate causing of death in newborns (“neonatal euthanasia”)

open access: yesAnaliza i Egzystencja, 2020
The problem of euthanasia in countries where this procedure is legal concerns patients who are capable of deciding on their own death. Consent to medically assisted acceleration of death is essential.
Bogna Wach
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Relational provisions from pets in the context of the family : implications for perceived social support and human health [PDF]

open access: yes
This thesis examines how the psychology of human relationships can be applied to the phenomenon of pet ownership. Current views on the origins of pet ownership and reasons for its popularity, and the application of concepts from the psychology of human ...
Bonas, Sheila Ann
core  

Jews and Anti-Jewish Rules in the Czech Codification of Church Law of 1349

open access: yesJournal on European History of Law, 2023
The first codification of church law in the territory of the historically Czech lands, known as the provincial statutes of Ernst of Pardubice (Statuta provinicialia Arnesti), was issued in 1349, with validity for the entire Prague archdiocese.
Lenka Šmídová Malárová
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

On the Fairness of Early Retirement Provisions [PDF]

open access: yes
Declining fertility and increasing longevity have rendered public pension systems in many OECD countries unsustainable and have triggered substantial reforms of these systems.
Friedrich Breyer, Stefan Hupfeld
core  

System Modeling: A Foundation for Costing Through-Life Availability Provision [PDF]

open access: yes, 2013
Under performance-guaranteeing contracts, such as availability-based contracts, the Original Equipment Manufacturers (OEMs) have become increasingly concerned with understanding and managing the cost of their commitment to deliver specific results to customer through-life.
Ettore Settanni   +2 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Legal Provisions and Union Leader Expectations for Enforcement of Quality of Work-Life Initiatives in Nepal

open access: yes, 2020
The purpose of this paper is to analyze the emerging views and approaches to work-life quality (QWL), legal provisions, and expectations of the union leader for the enforcement of QWL initiatives in Nepal.
Shrestha, Prakash, Parajuli, Dilip
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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