Results 171 to 180 of about 25,105 (301)

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Diagnostic value of lung function tests in long COVID: analysis of positive bronchial provocation test outcomes. [PDF]

Front Med (Lausanne)
Liu W, Feng Q, Yuan X, Lu C, Wang S, Yuan Y.   +5 more
europepmc   +1 more source

Simplifying the drug provocation test in non-immediate hypersensitivity reactions to amoxicillin in children: The experience of a tertiary care allergy unit. [PDF]

Pediatr Allergy Immunol, 2022
Liccioli G, Giovannini M, Caubet JC, Barni S, Sarti L, Parronchi P, Capone M, Tomei L, Mori F.   +8 more
europepmc   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Paroxysmal Atrial Fibrillation during Spasm Provocation Test with Acetylcholine: Clinical Characteristics of Patients and Effect on Coronary Microvascular Function Measurements. [PDF]

Rev Cardiovasc Med
Teragawa H, Oshita C, Hashimoto Y, Nomura S.   +3 more
europepmc   +1 more source

A Novel Movement-Evoked Pain Provocation Test for Older Adults With Persistent Low Back Pain: Safety, Feasibility, and Associations With Self-reported Physical Function and Usual Gait Speed. [PDF]

Clin J Pain, 2023
Simon CB, Hicks GE, Pieper CF, Byers Kraus V, Keefe FJ, Colón-Emeric C.   +5 more
europepmc   +1 more source

Follow-up Provocation Test in Patients with Coronary Artery Spasm

, 1994
Byung‐Hee Oh, Young Keun On, Ha Jin Lim, Dong Woon Kim, Dae Won Sohn, Myoung Mook Lee, Young Bae Park, Yun Shik Choi, Jung Don Seo, Young Woo Lee   +9 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Early recurrence of spontaneous coronary artery dissection: potential association with coronary vasospasm and optimal timing for spasm provocation test-a case series. [PDF]

Eur Heart J Case Rep
Endo T, Yunoki K, Miyahara K, Yamaguchi S, Namba Y, Yoshikawa M, Oka T.   +6 more
europepmc   +1 more source

A new perspective on acoustic rhinometry in terms of standardisation, including the nasal allergen provocation test. [PDF]

Postepy Dermatol Alergol, 2022
Krzych-Fałta E, Kaczyñska O, Samoliñski B, Sybilski A.   +3 more
europepmc   +1 more source