Results 271 to 280 of about 13,489,989 (410)

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

open access: yesAdvanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu   +9 more
wiley   +1 more source

Clinical Usefulness, Angiographic Characteristics, and Safety Evaluation of Intracoronary Acetylcholine Provocation Testing Among 921 Consecutive White Patients With Unobstructed Coronary Arteries [PDF]

open access: bronze, 2014
Peter Ong   +10 more
openalex   +1 more source

Multi‐Factor Optimization of Nickel Foam Flow Fields: Insights into Structural and Surface Modifications for High‐Performance PEMFCs

open access: yesAdvanced Science, EarlyView.
This article investigates the multi‐factor optimization of nickel foam flow fields in PEMFCs, focusing on compression, porosity, pore size, hydrophobicity, and surface coatings. Through comprehensive experiments and analysis, it reveals how structural and surface modifications influence electrochemical performance, water management, and corrosion ...
Siyuan Wu   +5 more
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao   +17 more
wiley   +1 more source

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