Results 141 to 150 of about 915,369 (314)

Proximity-based modelling of cross-contamination through agent-based simulation: a feasibility study [PDF]

, 2013
Proximity-based modelling methodology enables mathematical representation of a real system that is characterised by the existence of entities that come into physical contact.
Michael D. Williams (2110129), Eberhard E. Bischoff (21828569), Korina Katsaliaki (21813977), Navonil Mustafee (12647678)   +3 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Spaces of Innovation: learning, proximity and the ecological turn [PDF]

Contrary to the fashionable “death of distance” thesis, the socio-spatial context for innovation remains as important as ever for firms, networks and the public institutions that tend to be neglected in orthodox narratives of learning. In this article we
Kevin Morgan, Adrian Healy
core  

Requirements, specifications and deployment models for autonomous jobsite safety proximity monitoring [PDF]

, 2013
textConstruction has a higher injury and fatality rate than most of the other industries. Given this situation, existing research has studied various issues and factors affecting construction safety management and has attempted to use all available ...
Luo, Xiaowei
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Institutional attributes and parents’ contentment with the quality of teaching, care, and safety of pupils in public primary schools

Cogent Education
Parents' contentment with their child's education is the subject of a modest but increasing corpus of research. However, little has been done to identify specific school services that attract parents' attention.
Onyinye Chuktu, Valentine J. Owan, Kingsley B. Abang, Delight O. Idika, Effiom E. Ekpo, Esther E. Ekon, Felicia A.-O. Dan, Richard A. Ojini, Maria O. Sunday, Augustine I. Robert, Peter O. Aduma   +10 more
doaj   +1 more source

Best proximity theorems of proximal multifunctions [PDF]

Fixed Point Theory, 2021
Reza Ahmadi, Asadollah Niknam, Majid Derafshpour   +2 more
openaire   +1 more source

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis [PDF]

Ternary complexes, consisting of two proteins connected by small molecules like PROTACs or molecular glues pose new challenges for the analysis of molecular interactions, because they depend not only on binary affinities, but are orchestrated by ...
Ulrich, Rant, Alessio, Ciulli, Goran, Dahl, Irene, Ponzo, Charlotte, Crowe, Alice, Solda, Stefan, Geschwindner   +6 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source