Results 81 to 90 of about 1,611,351 (254)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Observation of the superconducting proximity effect in the surface state of SmB6 thin films

, 2016
The proximity effect at the interface between a topological insulator (TI) and a superconductor is predicted to give rise to chiral topological superconductivity and Majorana fermion excitations.
Fackler, Sean, Greene, Richard L., Lee, Seunghun, Liang, Yangang, Paglione, Johnpierre, Takeuchi, Ichiro, Wang, Xiangfeng, Yong, Jie, Zhang, Xiaohang   +8 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Andreev Reflection and Proximity effect [PDF]

, 1999
The Andreev Reflection is the key mechanism for the superconducting proximity effect. It provides phase correlations in a system of non-interacting electrons at mesoscopic scales, i.e.
Courtois, H., Pannetier, B.
core  

Absolute spin-valve effect with superconducting proximity structures

, 2001
We investigate spin dependent transport in hybrid superconductor(S)--normal-metal(N)--ferromagnet(F) structures under conditions of proximity effect. We demonstrate the feasibility of the absolute spin-valve effect for a certain interval of voltages in a
A. Brataas, A. Filip, A. Millis, D. Huertas-Hernando, Daniel Huertas-Hernando, E. Scheer, F. J. Jedema, G. A. Prinz, I. Malajovich, J. C. Cuevas, J. M. Kikkawa, J. R. Toplicar, J. Rammer, J. Vrba, M. A. M. Gijs, M. Fogelstrom, M. Tinkham, M. Zareyan, N. Moussy, R. Fiederling, R. Meservey, S. Datta, S. Guéron, S. M. Freake, T. Tokuyasu, Th. Gruber, W. Belzig, W. Belzig, W. J. Gallagher, W. L. McMillan, W. L. McMillan, Y. Ohno, Yu. V. Nazarov, Yu. V. Nazarov, Yu. V. Nazarov   +34 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transport and Point Contact Measurements on Pr_1−xCe_xPt₄Ge₁₂ Superconducting Polycrystals

Nanomaterials, 2020
We performed a detailed investigation of the superconducting properties of polycrystalline Pr1−xCexPt4Ge12 pellets. We report the effect of Ce substitution, for x = 0.07, on magnetic field phase diagram H-T.
Paola Romano, Francesco Avitabile, Angela Nigro, Gaia Grimaldi, Antonio Leo, Lei Shu, Jian Zhang, Antonio Di Bartolomeo, Filippo Giubileo   +8 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source