Results 111 to 120 of about 327,219 (245)

Proximal embolic protection with aspiration in percutaneous coronary intervention using the Proxis device.

Reviews in cardiovascular medicine, 2008
Distal embolization during primary percutaneous coronary intervention (PCI) occurs in at least 15% of patients and is a strong predictor of more extensive myocardial damage and a poor prognosis. Several devices are designed to evacuate the intracoronary thrombus or to prevent distal embolization.
Karel T, Koch, Joost D E, Haeck, René J, Van Der Schaaf, Frazil M, Alidjan, José P S, Henriques, Jan, Baan, Jan J, Piek, Allard C, Van Der Wal, Jan G P, Tijssen, Gabor, Sütsch, Robbert J, De Winter   +10 more
openaire   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Review of local alcohol harm reduction strategies in Cheshire and Merseyside [PDF]

, 2008
This report reviews local alcohol strategies in Cheshire and Merseyside.ChaMPs Public Health ...
Bridgman, Stephen, Cawley, Lucinda, Mann, Frances, Thurston, Miranda   +3 more
core  

Wide‐Range Adaptive Metal Oxide for Hydrogen Sulfide Detection From Earth to Space‐Like Environments

Advanced Science, EarlyView.
This work presents a gas sensing platform based on Cu‐doped SnO2 microspheres that operates reliably from ambient to space‐like conditions. The sensor maintains performance across vacuum and cryogenic environments, bypassing traditional oxygen‐mediated mechanisms, utilizing direct chemisorption and interfacial charge transfer.
Xi Chen, Jiaxin Chen, Yanghui Liu, Junhao Cao, Yang Yuan, Kaixin Chen, Yilang Ye, Tongshuai Yang, Yongqing Fu, Wei Luo   +9 more
wiley   +1 more source

ICU Admission Preferences in the Hypothetical Event of Acute Critical Illness: A Survey of Very Old Norwegians and Their Next-of-Kins

Critical Care Explorations
OBJECTIVES:. To explore older patients’ ICU admission preferences and their next-of-kins’ ability to predict these preferences. DESIGN:. Self-administered survey. SETTING:. Three outpatient clinics, urban tertiary teaching hospital, Norway.
Gabriele Leonie Schwarz, MD, Elisabeth Skaar, MD, PhD, Ingrid Miljeteig, MD, PhD, Karl Ove Hufthammer, PhD, Karen E. A. Burns, MD, MSc, FRCPC, Reidar Kvåle, MD, PhD, Hans Flaatten, MD, PhD, Margrethe A. Schaufel, MD, PhD   +7 more
doaj   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Open science interventions to improve reproducibility and replicability of research: a scoping review

Royal Society Open Science
Various open science practices have been proposed to improve the reproducibility and replicability of scientific research, but not for all practices, there may be evidence they are indeed effective.
Leonie Dudda, Eva Kormann, Magdalena Kozula, Nicholas J. DeVito, Thomas Klebel, Ayu P. M. Dewi, René Spijker, Inge Stegeman, Veerle Van den Eynden, Tony Ross-Hellauer, Mariska M. G. Leeflang   +10 more
doaj   +1 more source