Results 111 to 120 of about 18,370 (323)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Secure certificateless proxy re-encryption without pairing [PDF]

, 2017
A Proxy Re-encryption (PRE) is a cryptographic scheme for delegation of decryption rights. In a PRE scheme, a semi-honest proxy agent of Bob re-encrypts the ciphertext, on the message intended for Alice, on behalf of Bob, without learning anything about ...
Markowitch, Olivier, Kuchta, Veronika, Sharma, Gaurav, Gaurav Sharma, Sahu, Rajeev Anand, Veronika Kuchta, Olivier Markowitch, Bhatia, Tarunpreet Ms., Rajeev Anand Sahu, Tarunpreet Bhatia, Bhatia, Tarunpreet   +10 more
core   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

Secure sharing system with proxy re-encryption [PDF]

, 2015
This work introduces a new and secure mechanism for sharing files. In providing a complete implementation of a relatively recent cryptographic primitive known as proxy re-encryption, the thesis sharing system design enables file owners to store their ...
Salte, Morten
core  

Homomorphic Multi-Hop Proxy Re-Encryption for Data Aggregation [PDF]

, 2022
With the development of the Internet, to save the computation cost and storage space of hardware devices, people have begun to use cloud services more frequently. When data are stored in the cloud, there exist data leakage situations.
Lee, Meng-Lin
core  

Blockchain-Based Framework for Enhancing Interoperability and Security in EHR Exchange Using Lightweight ECC Proxy Re-Encryption

Acta Informatica Pragensia
Background: The sharing of electronic health records among hospitals is crucial for ensuring consistent patient treatment. However, the process remains challenging due to the existence of varied systems, privacy concerns and interoperability issues.
Devaramane Yogaraj Ashwini, Reval Prabhu Puneeth   +1 more
doaj   +1 more source

Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity

Advanced Science, EarlyView.
This work introduces a compact, low‐cost tabletop magnetic resonance elastography platform for high‐resolution viscoelastic mapping in soft‐tissue specimens. Using this method in human colorectal liver metastases, we demonstrate fully automated biomechanical profiling of treatment response and show that heterogeneity‐based metrics outperform ...
Weijie Zhao, Lisa‐Marie Skrip, Heiko Tzschätzsch, Tom Meyer, Hossein S. Aghamiry, Alexander Arnold, Lene Änne Böhne, Jakob Jordan, Oliver Boehm, Agnes K. Boehm, Steffen Görner, Jakob Schattenfroh, Yanglei Wu, Pedro Augusto Dantas de Moraes, Johann Pratschke, Jürgen Braun, Igor M. Sauer, Jing Guo, Ingolf Sack, Karl H. Hillebrandt   +19 more
wiley   +1 more source

Proxy Re-Encryption Scheme Supporting a Selection of Delegatees [PDF]

, 2014
International audienceProxy re-encryption is a cryptographic primitive proposed by Blaze, Bleumer and Strauss in 1998. It allows a user, Alice, to decide that in case of unavailability, one (or several) particular user, the delegatee, Bob, will be able ...
Eleonora Guerrini, Fabien Laguillaumie, Laguillaumie, Fabien, Guerrini, Eleonora, Devigne, Julien, Julien Devigne   +5 more
core   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source