Results 171 to 180 of about 82,842 (322)

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

The FEBS Journal, EarlyView.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt, Richard Strasser, Hong Zhu, Angelo Kaldis, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Paraptosis-related genes regulate tumor immune microenvironment and predict prognosis in breast cancer. [PDF]

J Cell Commun Signal
Dong Z, Yang Y, Zhu M, Liu H, Guo Y, Zhang H, Jiang Z.   +6 more
europepmc   +1 more source

The implementation of accurate pain reporting (APR) and placebo response reduction (PRR) training in clinical trials [PDF]

, 2020
Kathryn Evans, Ruth Werner, Nathaniel P. Katz   +2 more
openalex   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus. [PDF]

Viruses
Cui X, Liu S, An T.
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

The effects of PRRS on the environmental impact of pig production: a life cycle assessment study. [PDF]

Front Vet Sci
Thoma GJ, Galina Pantoja L, Linhares DCL, Serafini Poeta Silva AP, Case L, Knap PW.   +5 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Viral Vaccines as an Alternative to Antimicrobials: A Perspective from Swine Veterinarians on Challenges, Opportunities, and Future Directions. [PDF]

Pathogens
Li D, Zhang X, Apley MD, Gebhardt JT, Karriker L, Connor JF, Bromfield C, Lubbers B, Kittana H, Pendell D, Madera R, Muro N, Craig A, Shenkenberg B, Li Y, Wang L, Shi J.   +16 more
europepmc   +1 more source

OPTIMIZED FEATURE SELECTION BASED PREDICTIVE ROUND ROBIN SCHEDULING (OFS-PRRS)

, 2017
N. Arunadevi
openalex   +2 more sources