Results 21 to 30 of about 15,848 (137)
Литература двух Америк, 2020 Whitman’s reception is crucial to the history of World Literature in the 20th century. It involves especially transatlantic and hemispheric circulation.
Delphine Rumeau
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Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis [PDF]
, 2013 Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer’s disease (AD). AD is a complex disorder, characterised by several pathological features. The problem
Rafael Delgado Y Palacios +27 more
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Synaptic plasticity in the hippocampus of an APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice [PDF]
, 2010 Background Alzheimer disease (AD) is a neurodegenerative disorder for which there is no cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model (APPPS1-21) which expresses the Swedish mutation of APP and the L166P mutation of
Gengler Simon +8 more
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Introduction: Playing Metafictional Games with Percival Everett
Orbit, 2023 This introduction to the special issue on Percival Everett provides a general overview of his work for new readers and then discusses it in terms of metafiction and play, focusing especially on his 2022 novel Dr. No.
Sascha Pöhlmann
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The Power of Patriarchy: Everett’s Work on the Dionysus Myth in Frenzy
Orbit, 2023 This interpretation of Percival Everett's novel Frenzy focuses on the author's rewriting of the myth of Dionysus and other Greek myths referenced in the text, as it is through the revisions of classical versions of the myths that Everett expresses his ...
Christa Buschendorf
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Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]
, 2013 Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Vadivel Parthsarathy +7 more
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, 1998 Mutations in presenilin 1 (PS1) cosegregate with ∼25% of early onset familial Alzheimer's disease (FAD) pedigrees. A variety of in vitro and in vivo paradigms have established that one mechanism by which PS1 variants cause AD is by elevating the ...
Price, Donald L +8 more
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Plaque pathology increases with age in APP/PS1 and APP/PS1/htau animals.
, 2013 A. Immunohistochemical staining of 18-22 month-old WT, APP/PS1, htau, APP/PS1/htau brains. WT and htau brains are free of plaques. Scattered plaque deposition (black arrows) is detected in the outer layer of cortex in APP/PS1 and APP/PS1/htau brains, but
Hongmei Li (51944) +5 more
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Pathogenic PS1 phosphorylation at Ser367
, 2017 The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ...
Keller, Laura J +10 more
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Orbit, 2021 Book Reviews, of: Baskin – Ordinary Unhappiness: The Therapeutic Fiction of David Foster WallaceÖzcan – Understanding William T. VollmannEve – Thomas Pynchon and Philosophy: Wittgenstein, Foucault, AdornoCrews – Books are Made of
Ali Dehdarirad +7 more
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