Results 31 to 40 of about 20,648 (261)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Kadomtsev-Petviashvili hierarchies with non-formal pseudo-differential operators, non-formal solutions, and a Yang-Mills–like formulation

Physics Letters B
We start from the classical Kadomtsev-Petviashvili (KP) hierarchy posed on formal pseudo-differential operators, and we produce new hierarchies of non-linear equations in the context of non-formal pseudo-differential operators lying in the Kontsevich and
Jean-Pierre Magnot, Enrique G. Reyes
doaj   +1 more source

Blow-up time of solutions to a class of pseudo-parabolic equations

Comptes Rendus. Mécanique, 2023
In this paper, we study the Dirichlet problem for a semilinear pseudo-parabolic equation. By using the energy estimates and ordinary differential inequalities, we studied the upper and lower bounds of blow-up time of the solutions.
Zhou, Jun, Wang, Xiongrui
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

The Variational Principle for the Uniform Acceleration and Quasi-Spin in Two Dimensional Space-Time

Symmetry, Integrability and Geometry: Methods and Applications, 2008
The variational principle and the corresponding differential equation for geodesic circles in two dimensional (pseudo)-Riemannian space are being discovered.
Roman Ya. Matsyuk
doaj   +1 more source

On some perturbations of a stable process and solutions to the Cauchy problem for a class of pseudo-differential equations

Karpatsʹkì Matematičnì Publìkacìï, 2015
A fundamental solution for some class of pseudo-differential equations is constructed by the method based on the theory of perturbations. We consider a symmetric $\alpha$-stable process in multidimensional Euclidean space. Its generator $\mathbf{A}$ is a
M.M. Osypchuk
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Weighted pseudo almost automorphic functions with applications to impulsive fractional integro-differential equation

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2023
This paper’s main motivation is to study the notion of weighted pseudo almost automorphic (𝒲𝒫𝒜𝒜) functions and establish the existence results of piecewise continuous mild solution of fractional order integro-differential equation with instantaneous ...
Kavitha Velusamy, Arjunan Mani Mallika, Baleanu Dumitru, Grayna Jeyakumar   +3 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source