Results 181 to 190 of about 1,599,594 (296)

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source

Benchmarking cell-type deconvolution in cross-platform transcriptomic data. [PDF]

Genome Biol
Singh A, Cakmak P, Lun JH, Macas J, Plate KH, Reiss Y, Schupp J, Imkeller K.   +7 more
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

A Case of Pseudo-Richter Transformation Following Zanubrutinib Discontinuation in CLL. [PDF]

Mediterr J Hematol Infect Dis
Laurenti L, Quaranta T, Tomasso A, Stirparo L, Abbate PL, Bakacs A, Cappoli N, Di Napoli A, Efremov D, Bellisario F, Gattei V, Caldarella C, Calcagni ML, Autore F, Innocenti I.   +14 more
europepmc   +1 more source

CD34+ Progenitors Promote Ageing‐Associated Valve Sclerosis through the PDGFR–JNK–JUNB Pathway

Advanced Science, EarlyView.
In age‐related aortic valve sclerosis, non‐bone marrow CD34+ progenitor valvular interstitial cells (VICs) undergo transdifferentiation into periostin+ myofibroblast‐like VICs via the PDGFR‐JNK‐JUNB axis, driving leaflet thickening and fibrosis. Ablating non‐bone marrow CD34+ cells attenuates this remodeling.
Xiaoping Yang, Hong Wu, Guoqiang Ren, Yuesheng Zhang, Zuoshi Wen, Pengwei Zhu, Zhangquan Ying, Liujun Jiang, Tingting Tao, Bohuan Zhang, Linwen Zhu, Han Wang, Han Zhang, Qingbo Xu, Jun Cheng, Honghua Ye   +15 more
wiley   +1 more source

Context-dependent protein structure prediction analysis and complex stoichiometry inference with MultimerMapper. [PDF]

Front Bioinform
Rodríguez Araya E, Serra E.
europepmc   +1 more source

Fractional Variational Framework for Systems With Higher‐Order Elements. Part I: Lagrangian Construction and Equations of Motion

Advanced Electronic Materials, EarlyView.
This work introduces a physics‐consistent fractional variational framework for modeling systems with higher‐order elements. The developed methodology successfully incorporates energy dissipation, nonlinear dynamics, and memory effects into a unified Lagrangian formulation.
Dalibor Biolek, Viera Biolková, Zdeněk Biolek, Ivo Petráš, Jiří Petržela   +4 more
wiley   +1 more source

Passive sampling for grazer cues incorporates top-down effects in harmful algal bloom monitoring and toxin prediction. [PDF]

Proc Natl Acad Sci U S A
Trapp A, Behncké-Serra A, Selander E, Peacock MB, Kudela RM.   +4 more
europepmc   +1 more source

Integrating Automated Electrochemistry and High‐Throughput Characterization with Machine Learning to Explore Si─Ge─Sn Thin‐Film Lithium Battery Anodes

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
A closed‐loop, data‐driven approach facilitates the exploration of high‐performance Si─Ge─Sn alloys as promising fast‐charging battery anodes. Autonomous electrochemical experimentation using a scanning droplet cell is combined with real‐time optimization to efficiently navigate composition space.
Alexey Sanin, Jackson K. Flowers, Tobias H. Piotrowiak, Frederic Felsen, Leon Merker, Alfred Ludwig, Dominic Bresser, Helge Sören Stein   +7 more
wiley   +1 more source

Near-duplicate contamination inflates brain MRI benchmark performance: a size-matched, multi-seed MedNeXt-B study. [PDF]

Front Med (Lausanne)
Huang Y, Sun Z, Chen J, Yang T, Xie L, Lin X.   +5 more
europepmc   +1 more source