Results 241 to 250 of about 1,599,594 (296)

Integrating Genetic Modifier Genotype With Serum Proteomics in Duchenne Muscular Dystrophy Clinical Trials Links LTBP4 Genetic Modifier to IL‐23/CD93 Pathways in Muscle

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genetic modifiers of Duchenne muscular dystrophy (DMD) that alter disease severity or response to therapy have been reported using natural history or registry data sets of older corticosteroid‐treated patients. We tested associations of genetic modifiers on motor function outcomes in young (4 to < 7 years) steroid naïve clinical trial ...
Utkarsh J. Dang, Yuan Fang, Daniele Sabbatini, Elena Pegoraro, Luca Bello, Paula R. Clemens, Michela Guglieri, John van den Anker, Jesse Damsker, Laura Hagerty, Yetrib Hathout, Michael Ziemba, Lauren Morgenroth, Surajit Bhattacharya, Kanneboyina Nagaraju, Jyoti K. Jaiswal, Eric P. Hoffman   +16 more
wiley   +1 more source

Online capacitance-integrated development of a hybrid bioprocess model for industrial fungal fermentations. [PDF]

Front Bioeng Biotechnol
Lemperle M, Kager J, Cassells B, Stocks SM, Gernaey KV, Ramin P.   +5 more
europepmc   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Normal Tail Suppression for Low-False-Positive RGB-3D Industrial Anomaly Localization. [PDF]

J Imaging
Zhu G, Ji Z, Wu Z, Dai J, Chen W, Liu H.
europepmc   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +1 more source

st2traj: deconvolution-informed trajectory inference for multi-timepoint spatial transcriptomics. [PDF]

Bioinformatics
Wang Z, Zhang C.
europepmc   +1 more source

Zombies without puppeteers: Morgan's Canon and the passive manipulation hypothesis in <i>Xenos vesparum</i>/<i>Polistes dominula</i>. [PDF]

Front Parasitol
Starks PT.
europepmc   +1 more source

Multiparametric MRI radiomics integrating Arterial Spin Labeling, Quantitative Susceptibility Mapping, and Amide Proton Transfer imaging for differentiating glioma recurrence from post-treatment response. [PDF]

Front Oncol
Wang Q, Yuan Z, Diao Y, Si Y, Dong S, Lv X, Liang H.   +6 more
europepmc   +1 more source

Case Report: A rare case of multiple gastrointestinal autoimmune disorders mimicking autoimmune polyglandular syndrome type 3B. [PDF]

Front Immunol
Zhang Z, Xie Y, Zhang T, Li X, Wang A, Wu Z, Cai R, Zhang S.   +7 more
europepmc   +1 more source