Results 51 to 60 of about 1,006,016 (305)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A Son of Nikon or Nikon Victorious: A New Inscription on a Fragment of a Pseudo Panathenaic Amphora

open access: yesArts, 2022
Recently, an inscribed fragment of a closed vase made of buff pinkish clay, covered with a red-orange wash, 11.8 cm wide and 8.4 cm high, and decorated with black, lustrous clay-paint surfaced briefly on the Swiss art market. It preserves a small section
Thomas Mannack
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Liquidity Constraints and Durable/Non-durable Consumption Relationship in Iran

open access: yesبرنامه‌ریزی و بودجه, 2019
In a rational expectation utility optimization model, the consumption profile is smoothed over time and, under some simplifying assumptions, it equals a constant fraction of total lifetime income.
Zahra Shahidi   +2 more
doaj  

Measuring Non-Linear Absolute Mobility in Distribution of Income in Iran [PDF]

open access: yesپژوهشهای اقتصادی, 2016
In most countries, there is no panel data for different households over time. However, cross-sectional data are usually available. Using a cross-sectional dataset, a given group of households cannot be examined for subsequent years. To solve this problem,
Hossein Raghfar   +2 more
doaj  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett   +8 more
wiley   +1 more source

Estimating individual vulnerability to poverty with pseudo-panel data [PDF]

open access: yes, 2004
This paper presents an original method to study individual earning dynamics using repeated cross-sectional data. Because panel data of individuals are seldom available in developing countries, it is difficult to study individual earning dynamics and related issues such as the propensity of earners to fall into poverty or vulnerability to poverty ...
Bourguignon, Francois   +2 more
openaire   +2 more sources

Bilgi ve iletişim teknolojileri kullanımının mikro belirleyicileri: Pseudo panel veri analizi

open access: yesAfyon Kocatepe Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
Bu çalışma Türkiye için bilgi ve iletişim teknolojileri (BİT) kullanımını etkileyen olası faktörleri belirlemeyi amaçlamaktadır. Bu amaçla, 2016-2021 dönemine ilişkin altı yıllık bir mikro veri seti kullanılarak BİT yaygınlığı incelenmiştir.
Berat Harman, Zehra Abdioğlu
doaj   +1 more source

Efecto del acceso al programa Familias en Acción sobre la participación política de las mujeres en Colombia

open access: yesRevista Tiempo & Economía, 2022
Este documento analiza el alcance de los programas sociales focalizados con transferencias condicionadas en la participación política femenina. Para ello hace un estudio de caso del programa Familias en Acción en Colombia entre los años 2007-2014 ...
Lorena Andrea López Barrera
doaj   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree   +9 more
wiley   +1 more source

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