Results 71 to 80 of about 12,065 (169)

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Measuring adherence to therapy in apparent treatment-resistant hypertension: a feasibility study in Irish primary care

, 2019
BACKGROUND: Apparent treatment-resistant hypertension (aTRH) is defined as uncontrolled blood pressure (BP) in patients taking three or more antihypertensive medications.
Glynn, Liam G, Ann Connelly (8250843), Liam G. Glynn (7945415), PETER HAYES (12348886), O\u27Brien, Eoin, Monica Casey (12348721), David Finn (8797307), Eoin O'Brien (7949450), Newell, John, Casey, Monica, Hannah Durand (3417071), Dolan, Eamon, Das, Kishor, Conneely, Ann, Brendan Harhen (12595000), Das Kishor (12594997), Molloy, Gerard J., Kishor,Das,, Murphy, Andrew W, Molloy, Gerard J, Andrew W. Murphy (7937078), Durand, Hannah, Murphy, Andrew W., Gerard J. Molloy (7938227), Hayes, Peter, O’Brien, Eoin, Finn, David, Harhen, Brendan, Connelly, Ann, Eamon Dolan (7512773), Glynn, Liam G., John Newell (114330)   +31 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Cardiovascular outcome in treated hypertensive patients with responder, masked, false resistant, and true resistant hypertension.

, 2005
Background: The aim of this study was to evaluate the cardiovascular outcome in apparently responder hypertensive patients with responder and masked hypertension, and in apparently resistant hypertensive patients with false and true resistant ...
CALDARELLA, Maria Pia Michela, PIERDOMENICO, Sante Donato, LAPENNA, Domenico, BUCCI, Anna, DI TOMMASO, ROBERTA, CUCCURULLO, Franco, DI MASCIO, RAFFAELLA, NERI, Matteo, MANENTE BM, MEZZETTI, Andrea   +9 more
core   +1 more source

Prognostic impact of fibrinogen in patients with resistant hypertension

In this study, we investigated the long-term prognostic effects of fibrinogen levels in patients with resistant hypertension. A total of 266 patients with resistant hypertension who had serum fibrinogen measurements and 5 years of follow-up information ...
Ahmet Avcı, Mustafa Umut Somuncu, Hamdi Püşüroğlu, Mehmet Ertürk, İlyas Çetin, Uğur Köktürk   +5 more
core   +1 more source

Resistant hypertension: an approach to management in primary care

, 2015
Hypertension is widely encountered in family medicine. Despite its prevalence, many patients have uncontrolled or difficult-to-control blood pressure. Resistant hypertension is defined as hypertension that is poorly responsive to treatment and requires ...
Thambar, Sam V, Sam V Thambar, Yaxley, Julian P, Julian P Yaxley   +3 more
core   +1 more source

True Resistant Hypertension Following Observed Drug Ingestion: A Systematic Evaluation

, 2016
The authors investigated the role of poor drug adherence in treatment-resistant hypertension following observed drug ingestion in 102 patients. Median blood pressures (BPs) were 170/91 mm Hg at referral, 153/84 mm Hg prior to, and 142/79 mm Hg during a 4-
Neil Chapman, Chang, CL, Thornton-Jones, L, Simon Thom, Bunker, J, Choon‐Lan Chang, Chapman, N, Poulter, N, Peter Sever, Jill Bunker, Neil Poulter, Thom, S, Sever, P, Lucy Thornton‐Jones   +13 more
core   +1 more source

Hipertensão pseudo-resistente causada por baixa adesão terapêutica

Revista de Ciências Farmacêuticas Básica e Aplicada, 2015
Este estudo teve como objetivo identificar pacientes com hipertensão arterial pseudo-resistente causada pela não-adesão terapêutica. Foi realizado um estudo transversal com pacientes com hipertensão atendidos pela Estratégia de Saúde da Família.
Alfredo Dias Oliveira-Filho, Anna Karla Cesar Leandro, Mirela Quirino Almeida, Divaldo Pereira Lyra Junior, Sabrina Joany Felizardo Neves   +4 more
doaj  

When and how to use ambulatory blood pressure monitoring and home blood pressure monitoring for managing hypertension

Clinical Hypertension
Many individuals have different blood pressure (BP) values in the office setting compared to that outside the office setting. Therefore, confirming hypertension based on office BP (OBP) measurement alone can lead to misdiagnosis and mistreatment.
Eun Mi Lee
doaj   +1 more source

Diagnosis and management of resistant hypertension: state of the art

, 2018
Resistant hypertension is defined as a lack of ambulatory blood pressure response to optimized medical treatment after exclusion of secondary hypertension in patients who are fully adherent to antihypertensive therapy.
Staessen, Jan A., Fang-Fei Wei, Jan A. Staessen, Wei, F.F., Zhen-Yu Zhang, Huang, Qi-Fang, Qi-Fang Huang, Zhang, Z.Y., Huang, Q.F., Staessen, J.A., Zhang, Zhen-Yu, Wei, Fang-Fei   +11 more
core   +1 more source