Results 151 to 160 of about 73,502 (293)

Value in the ‘valley of the shadow of death’—When the user is no longer the value arbiter

open access: yesAustralian Journal of Public Administration, EarlyView.
Abstract The Public Service Logic (PSL) user‐centric perspective on value creation has been one of its main critiques. Scholars argue that for some real‐world applications, such as emergency services, where users cannot engage with service offerings, the PSL must consider the roles of other service actors beyond just facilitators.
Higor Leite, Stephen Osborne
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

open access: yesAllergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter   +20 more
wiley   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

open access: yesAllergy, EarlyView.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton   +19 more
wiley   +1 more source

Effect of Medication Intake on Dental Implant‐Related Outcomes—A Scoping Review

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objective The objective of this scoping review was to evaluate the effect of systemic medications on dental implant outcomes in medically compromised patients. Material and Methods Electronic and manual searches were conducted for this scoping review.
Alberto Monje   +4 more
wiley   +1 more source

PSO-OCSVM based industrial control system communication behavior anomaly detection method

open access: yes, 2016
本发明基于OCSVM算法提出了一种基于PSO-OCSVM的工业控制系统通信行为异常检测方法。该发明利用改进的单类支持向量机算法,根据正常的Modbus功能码序列建立正常通信行为轮廓,设计了一种基于粒子群算法(PSO)进行参数优化的PSO-OCSVM方法,建立入侵检测模型,识别出异常的Modbus?TCP通信流量。该发明提高了异常检测的效率及其可靠性 ...
于海斌   +4 more
core  

Impact of adalimumab treatment on impairment of non‐professional activities in psoriasis patients

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Psoriasis can result in reduced quality of life, work productivity loss, and a significant restriction in non‐professional activities. This study investigates the effects of long‐term treatment with adalimumab regarding work ability, non‐professional activities, and health‐related quality of life in a large real‐word ...
Georgios Kokolakis   +4 more
wiley   +1 more source

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