Results 1 to 10 of about 1,635 (133)
Paradoxical psoriasiform reactions during treatment with adalimumab for hidradenitis suppurativa: Real-life experience and therapeutic response to other biological drugs. [PDF]
Dermatol Ther, 2022 Abstract Adalimumab is the only biological drug approved to date for the treatment of moderate and/or severe hidradenitis suppurativa. Adverse events reported during therapy include paradoxical psoriasiform reactions. No guidelines are currently available for the management of this clinical condition.
Burzi L +5 more
europepmc +2 more sources
Real-life effectiveness of tildrakizumab in chronic plaque psoriasis: A 52-week multicentre retrospective study-IL PSO (Italian landscape psoriasis). [PDF]
J Eur Acad Dermatol Venereol, 2023 Abstract Background Tildrakizumab is a humanized monoclonal antibody that binds selectively the p19 subunit of interleukin‐23. It is approved for treatment of moderate–severe chronic plaque psoriasis. Objectives We conducted a 52‐week retrospective study to assess the effectiveness and safety of tildrakizumab in a real‐life setting.
Narcisi A +19 more
europepmc +2 more sources
Artificial intelligence processing electronic health records to identify commonalities and comorbidities cluster at Immuno Center Humanitas. [PDF]
Clin Transl Allergy, 2022 Abstract Background Comorbidities are common in chronic inflammatory conditions, requiring multidisciplinary treatment approach. Understanding the link between a single disease and its comorbidities is important for appropriate treatment and management.
Morandini P +10 more
europepmc +2 more sources
The Oxidative Stress-Induced miR-200c Is Upregulated in Psoriasis and Correlates with Disease Severity and Determinants of Cardiovascular Risk. [PDF]
Oxid Med Cell Longev, 2019 Psoriasis is a chronic inflammatory skin disease associated with reactive oxygen species (ROS) increase and a higher risk of cardiovascular (CV) events. We previously showed that the miR‐200 family (miR‐200s) is induced by ROS, miR‐200c being the most upregulated member responsible for apoptosis, senescence, ROS increase, and nitric oxide decrease ...
Magenta A +12 more
europepmc +2 more sources
Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psoriasis. [PDF]
J Immunol Res, 2018 IFN‐γ and IL‐22 are deeply involved in the pathogenesis of psoriasis, as they boost the expression of inflammatory genes and alter proliferative and differentiative programs in keratinocytes. The JAK1/JAK2/STAT1 and JAK1/TYK2/STAT3 pathways triggered by IFN‐γ and IL‐22, respectively, are aberrantly activated in psoriasis, as highlighted by the peculiar
Morelli M +7 more
europepmc +2 more sources
Cutis, 2021 A Elbow and forearm with erythematous, well-demarcated, pink plaques with mild micaceous scale in a 42-year-old White woman. B Elbow and forearm with violaceous, well-demarcated plaques with micaceous scale and hyperpigmented patches around the active plaques in a 58-year-old Black man.
Candrice R, Heath, Richard P, Usatine
openaire +4 more sources
Der Hautarzt, 2016 Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations and substantial negative effects on patient quality of life. Psoriasis has a strong, albeit polygenic, genetic basis. Whereas approximately half of the accountable genetic effect of psoriasis maps to the major histocompatibility complex, >70 other loci have been
Sabat, Robert +2 more
+10 more sources
Annual Review of Pathology: Mechanisms of Disease, 2012 Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis.
Ulrich Mrowietz, Jörg Christoph Prinz
+9 more sources
Therapeutische Umschau, 2010 Die Psoriasis ist eine Hautkrankheit, die sich nach außen hin durch scharf begrenzte, gerötete Plaques infolge entzündlicher Hautinfiltration und einer fest haftenden, silbrig weißen Schuppung infolge epidermaler Hyperproliferation und Parakeratose auszeichnet.
Navarini, Alexander A., Trüeb, Ralph M.
+8 more sources
New England Journal of Medicine, 2005 Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated comorbidity.
Boehncke, Wolf-Henning +1 more
openaire +6 more sources