Results 231 to 240 of about 90,167 (303)

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

The comparative prevalence of comorbidities across rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. [PDF]

Rheumatol Adv Pract
Williams JC, Southworth J, Rogers K, Zhao SS.   +3 more
europepmc   +1 more source

Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential

MedComm, Volume 6, Issue 11, November 2025.
This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/presentation, adaptive immunity activation, immune tolerance induction, and regulation of innate immune cells).
Fangfang Jin, Lingxiang Xie, Hongqi Zhang, Xiang Fan, Jiaxing Tian, Wei Liu, Yang Xiao, Xinrong Fan   +7 more
wiley   +1 more source

High prevalence of MASLD in psoriasis and psoriatic arthritis assessed with multiparametric magnetic resonance imaging. [PDF]

Rheumatology (Oxford)
James L, Diamond C, Al-Mossawi H, Andersson A, Pandya P, Shumbayawonda E, Izadi Firouzabadi L, Watson L, Savage LJ, Thomaides-Brears H, Banerjee R, Coates LC.   +11 more
europepmc   +1 more source

Decision letter for "TLR7 endogenous ligands remodel glycolytic macrophages and trigger skin‐to‐joint crosstalk in psoriatic arthritis"

, 2020

openalex   +1 more source

Long‐Term Safety Evaluations in the Presence of Switching: Evaluation of Two Approaches

Pharmaceutical Statistics, Volume 24, Issue 6, November/December 2025.
ABSTRACT Evaluating the long‐term safety of approved drugs for chronic indications is essential. This assessment ensures that the benefits continue to outweigh the risks beyond the follow‐up observed in the clinical trials supporting market authorization.
Sandra Schmeller, Rima Izem, Pedro Lopez Romero, Valentine Jehl   +3 more
wiley   +1 more source

The development of a clinical prediction model for response to methotrexate, tofacitinib, and etanercept in patients with Psoriatic Arthritis. [PDF]

Arthritis Res Ther
Perton FT, Bentvelzen MLM, Fadaei S, Pouw JN, Spierings J, Vonkeman HE, Mooij SC, Schipper LG, Herman A, TOFA-PREDICT author group, Mastbergen SC, Welsing PMJ.   +11 more
europepmc   +1 more source

Cultured Meat Reformulation: Health Potential and Sustainable Food Challenges—Narrative Review

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 6, November 2025.
ABSTRACT Cellular meat is the result of an innovative technology that facilitates the production of meat through the cultivation of animal cells in controlled laboratory environments. This process reduces the negative impact of traditional animal farming on the environment and creates the possibility of optimizing the nutritional composition, which can
Marek Kardas, Wiktoria Staśkiewicz‐Bartecka, Aleksandra Kołodziejczyk   +2 more
wiley   +1 more source

Variability of Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) thresholds in psoriatic arthritis: data from the ReFlaP study. [PDF]

Rheumatology (Oxford)
López-Medina C, Gorlier C, Orbai AM, Coates LC, Kiltz U, Leung YY, Palominos P, Cañete JD, Cañete JD, Scrivo R, Balanescu A, Dernis E, Meisalu S, Ruyssen-Witrand A, Soubrier M, Aydin SZ, Eder L, Gaydukova I, Lubrano E, Kalyoncu U, Richette P, Husni ME, Smolen JS, de Wit M, Gossec L.   +24 more
europepmc   +1 more source

Microenvironment‐Driven Mast Cell Plasticity: Insights From Cytokine‐Activated Gene Signatures in Skin and Respiratory Diseases

Allergy, Volume 80, Issue 11, Page 3077-3094, November 2025.
Primary peripheral blood‐derived human mast cells exposed to IFNγ, IL‐33, IL‐4 + IL‐13, or TGFβ develop distinct transcriptional signatures with unique functional changes including degranulation and cytokine/chemokine release. Machine learning‐defined minimal cytokine‐activated signatures (245 genes) successfully detect cytokine‐primed mast cells in ...
Chiara Tontini, Rajia Bahri, Andrew Higham, Dave Singh, Angela Simpson, Silvia Bulfone‐Paus   +5 more
wiley   +1 more source