A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered ‘early’?
Timely recognition of inflammatory and autoimmune rheumatic diseases (IARDs) is important to optimize the early diagnosis with tailored interventions and possible prevention of irreversible organ damage. This narrative review provides an update by summarizing the advances in identifying the early stages of rheumatoid arthritis, systemic sclerosis and ...
Elvis Hysa +7 more
wiley +1 more source
Antisynthetase Syndrome Masquerading As Psoriasis and Psoriatic Arthritis: A Case Report. [PDF]
Chow EY, Tran KH, Lai R.
europepmc +1 more source
Reduced EZH2 Expression in Circulating CD8‐Positive T Cells and Monocytes in Psoriasis
ABSTRACT Enhancer of Zeste Homologue 2 (EZH2) is an epigenetic regulator involved in immune cell differentiation and function; however, its role in psoriasis remains unknown. This study aimed to evaluate EZH2 expression in peripheral blood mononuclear cells from patients with psoriasis and explore its potential functional relevance to disease ...
Toyoki Yamamoto +5 more
wiley +1 more source
Dual biologic therapy in a patient with severe psoriasis and psoriatic arthritis, using guselkumab and bimekizumab: A case report and review of the literature. [PDF]
Muylaert Barrett B, Music M, Yadav G.
europepmc +1 more source
What Is the Diagnostic Capacity of Existing Severity Scoring Tools for Nail Psoriasis?
ABSTRACT Background It is challenging to distinguish nail psoriasis (NP) from nonspecific nail changes, contributing to heterogeneity in clinical trials. Existing scoring tools for NP are currently used to assess severity after diagnosis is established.
Evi C. C. Rikken +5 more
wiley +1 more source
Dual-platform urinary metabolomics identifies candidate diagnostic biomarkers in Psoriatic Arthritis. [PDF]
Peddi K +8 more
europepmc +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 1, January 2026.
Yu‐Han Alice Hsu +2 more
wiley +1 more source
Mitochondrial Activity Regulates Human T Helper 17 Differentiation and Function
Naïve CD4+ T cells differentiating into RORγt+IL‐17A+ Th17 cells are characterised by a shift from glycolysis to oxidative phosphorylation. Early‐stage cells favour glycolysis, whereas later‐stage cells with hyperpolarised mitochondrial membrane potential (ΔΨ) rely more on oxidative phosphorylation, show increased activation, and differentiate more ...
Xinlai Chen +10 more
wiley +1 more source
Variability of Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) thresholds in psoriatic arthritis: data from the ReFlaP study. [PDF]
López-Medina C +24 more
europepmc +1 more source
The comparative prevalence of comorbidities across rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. [PDF]
Williams JC +3 more
europepmc +1 more source

