Results 81 to 90 of about 494,085 (317)

Clonal sharing of CD8+ T‐cells links skin and joint inflammation in psoriatic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Psoriatic arthritis (PsA) is an HLA class I‐associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T‐cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J.A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization [PDF]

, 2012
Introduction: In recent genome-wide association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities.
Apel, Maria, Behrens, Frank, Burkhardt, Harald, Böhm, Beate B., Hüffmeier, Ulrike, Reis, André, Uebe, Steffen   +6 more
core   +2 more sources

Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Juvenile idiopathic arthritis (JIA) patients frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in JIA patients remains elusive. Methods Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with ...
Viola Pitkänen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna‐Mari Schroderus, Liisa Kröger, Tuure Kinnunen   +13 more
wiley   +1 more source

Clinical efficacy, radiographic and safety findings through 2 years of golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of the randomised, placebo-controlled GO-REVEAL study [PDF]

, 2013
Objectives: To assess long-term golimumab efficacy/safety in patients with active psoriatic arthritis (PsA).<p></p> Methods Adult PsA patients (≥3 swollen, ≥3 tender joints, active psoriasis) were randomly assigned to ...
Beutler, A., Gladman, D.D., Kavanaugh, A., Krueger, G.G., Mack, M., McInnes, I.B., Mease, P.J., Mudivarthy, S., van der Heijde, D., Xu, W., Xu, Z.   +10 more
core   +1 more source

Late‐Onset Spondylarthritis Presenting as Glucocorticoid‐Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where TNF or IL‐17 Blockade may have a Therapeutic Role

Arthritis &Rheumatology, Accepted Article.
Background Polymyalgia rheumatica (PMR) is an age‐related inflammatory disease with shoulder‐hip girdle involvement. Magnetic resonance imaging (MRI) reveals extracapsular/entheseal soft tissue involvements in both PMR and spondyloarthritis (SpA) with sacroiliac joint and peri‐entheseal spinal bone marrow oedema (BMO) being characteristic of SpA ...
Kerem Abacar, Gabriele De Marco, Jake Weddell, Katya Meridor, Tom Macleod, Andrew Scarsbrook, Kulveer Mankia, Edward Vital, Andrew Barr, Colin Pease, Helena Marzo‐Ortega, Sarah L. Mackie, Dennis McGonagle   +12 more
wiley   +1 more source

Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort. [PDF]

, 2019
IntroductionSleep is essential for overall health and well-being, yet more than one-third of adults report inadequate sleep. The prevalence is higher among people with psoriasis, with up to 85.4% of the psoriatic population reporting sleep disruption ...
Armstrong, April W, Beck, Kristen, Bell, Stacie J, Bhutani, Tina, Boas, Marc, Bridges, Alisha, Doris, Frank, Gelfand, Joel M, Lafoy, Brian, Liao, Wilson, Ly, Karen, Orbai, Ana-Maria, Shankle, Lindsey, Siegel, Michael P, Smith, Mary Patricia, Takeshita, Junko, Thibodeaux, Quinn, Truman, Sarah, Wan, Marilyn T, Weerasinghe, Thulasi, Wu, Jashin J   +20 more
core   +1 more source

Methotrexate in Psoriasis and Psoriatic Arthritis

Journal of Rheumatology Supplement, 2020
Methotrexate (MTX) is the most commonly prescribed first-line therapy in psoriatic arthritis (PsA) internationally and is also commonly used in the treatment of psoriasis. However, data supporting its use in PsA are limited and significant toxicities can
L. Coates, J. Merola, S. Grieb, P. Mease, K. Callis Duffin   +4 more
semanticscholar   +1 more source

B cells and systemic sclerosis interstitial lung disease

Arthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman, Voon Ong, Christopher Denton   +2 more
wiley   +1 more source

The metabolomics of psoriatic disease. [PDF]

, 2017
Metabolomics is an emerging new "omics" field involving the systematic analysis of the metabolites in a biologic system. These metabolites provide a molecular snapshot of cellular activity and are thus important for understanding the functional changes ...
Afifi, Ladan, Chang, Hsin Wen, Jeon, Caleb, Lee, Kristina, Liao, Wilson, Trivedi, Megha, Yan, Di   +6 more
core  

Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans [PDF]

, 2016
Preclinical studies demonstrate that pro-inflammatory cytokines increase serotonin transporter availability and function, leading to depressive symptoms in rodent models.
Burden, A. David, Cavanagh, Jonathan, Combet, Emilie, Hadley, Donald, Krishnadas, Rajeev, Leman, Joyce, McInnes, Iain B., Nicol, Alice, Pimlott, Sally, Puri, Navesh, Sassarini, Jen   +10 more
core   +1 more source