Results 91 to 100 of about 14,394 (262)
Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe +15 more
wiley +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Introduction Pediatric ambulatory surgery has become the dominant model of surgical care in the United States, driven primarily by economic forces. There is variability in regional practice patterns, quality improvement cycles, and outcomes. Opportunity exists to overcome knowledge gaps and provide sustainable pathways of quality improvement ...
Jennifer L. Chiem +6 more
wiley +1 more source
Sodium Ions Affect GPR17 Conformational States and Functionality
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo +6 more
wiley +1 more source
Regional Sustainability Assessment Under Risk and Uncertainty: A Water–Energy–Food Based Framework
Sustainable Development, EarlyView.ABSTRACT Regional sustainability assessment requires integrated structures that can examine the interactions between Water–Energy–Food (WEF) systems, socio‐economic risk conditions, and performance outcomes under uncertainty. This study proposes a multidimensional framework that combines a suitability index, composite sustainability indicators ...
Murat Oturakci
wiley +1 more source
Durability performance of a high‐performance fiber‐reinforced concrete for bridge applications
Structural Concrete, EarlyView.Abstract This paper investigates the durability performance of a coarse‐aggregate high‐performance fiber‐reinforced concrete (HPFRC) developed as a cost‐efficient material solution for precast bridge applications. A comprehensive experimental program was conducted to assess the resistance of the material to the principal deterioration mechanisms ...
Rolando Baldiviezo +6 more
wiley +1 more source
COMPETIÇÃO DE CULTIVARES DE ALFACE-AMERICANA NO SUL DE MINAS GERAIS
Revista Caatinga, 2006 Aiming to evaluate crisp head lettuce cultivars adapted to summer, showing tip burn¿s tolerance caused by calcium deficiency, an experiment was conducted in Santana da Vargem, MG, comprising the Lucy Brown, PSR 1114, PSR 1115, PSR 0110, PSR 5338, PSR ...
Jony Eishi Yuri +3 more
doaj
Thunderbird International Business Review, EarlyView.ABSTRACT The paper explores the evolving relationship between decarbonization strategies, environmental performance within ESG frameworks, and the economic performance of multinational companies in the context of increasing environmental and geopolitical uncertainty.
Maurizio Pompella, Lorenzo Costantino
wiley +1 more source
Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models
Environmental Toxicology, EarlyView.ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa +9 more
wiley +1 more source
A Contingency Argument Without the PSR
Traditional cosmological arguments are often thought to rely fatally on the Principle of Sufficient Reason. This paper develops a contingency argument that does not. Building on Armstrong’s metaphysics, I propose that no non-empty world is accessible from an empty world.
openaire +3 more sources
Maternal Lead Exposure Induces Glandular Alterations in the Salivary Glands of Rat Male Offspring
Environmental Toxicology, EarlyView.ABSTRACT Lead (Pb) is a widely distributed environmental pollutant that is highly noxious due to its toxicokinetic characteristics. Pb exposure can damage vital organ systems, including the central nervous and stomatognathic systems. As salivary glands play an important role in oral homeostasis, this study aimed to investigate the effects of maternal ...
Rayssa Maitê Farias Nazário +8 more
wiley +1 more source