Results 41 to 50 of about 234,501 (297)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

The Role of the Psychic Guilt Theory in Establishing Liability in Civil Law

open access: yesПсихология и право, 2021
The present publication deals with one of the most significant intersections of two social sciences: psychology and civil law, creating both a field of research and a concept such as psychical guilt.
Monastyrskiy Yu.E.
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Atonement and the Cry of Dereliction from the Cross [PDF]

open access: yes, 2012
Any interpretation of the doctrine of the atonement has to take account of relevant biblical texts. Among these texts, one that has been the most difficult to interpret is that describing the cry of dereliction from the cross. According to the Gospels of
Eleonore, Stump
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Perder e recuperar a alma: tendências recentes na psicologia social da religião norte-americana e européia

open access: yesPsicologia: Teoria e Pesquisa
A palavra alma, do vocabulário religioso e psicológico, desapareceu da linha-mestra da psicologia. Com ela desapareceu o conceito de uma instância essencial da realidade humana.
Geraldo José de Paiva
doaj   +1 more source

Peculiarities of the mental and motility state of the children suffering from mental retardation and postural disorders

open access: yesНауковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2020
Nowadays, there are numerous scientific reviews and studies devoted to the problem of psychomotor retardation of children of different ages. Though, a comprehensive solution of how to identify psychophysical characteristics demonstrated by this category ...
Biesieda Volodymyr
doaj   +1 more source

The Self [PDF]

open access: yes, 2008
The Self is an inquiry into the concepts of self, soul, person, ego, consciousness, psyche and mind – ranging over phenomenology, logic, epistemology, ontology, psychology, spirituality, meditation, ethics and metaphysics.
Sion, Avi
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Animal Pneuma: Reflections on Environmental Respiratory Phenomenology

open access: yesPhilosophies
This essay is an attempt to propose an outline of a new respiratory animal philosophy. Based on an analysis of the forgetting of breath in Western philosophy, it aims to gesture towards a future, breathful and compassionate world of co-sharing and co ...
Lenart Škof
doaj   +1 more source

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