Results 131 to 140 of about 1,312,023 (288)

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia   +19 more
wiley   +1 more source

Brain‐wide magnetic resonance imaging analysis of neurobehavioral comorbidities in temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely understood.
Fatemeh Fadaie   +4 more
wiley   +1 more source

Limited sex‐specific structural alterations across common epilepsies: A worldwide ENIGMA study

open access: yesEpilepsia, EarlyView.
Abstract Objective Epilepsy is characterized by widespread cortical and subcortical structural alterations beyond the epileptic zone. Importantly, the clinical manifestation of epilepsy, including seizure types, psychiatric comorbidities, and treatment responses, has been shown to differ between sexes. However, sex differences in structural alterations
Huantao Wen   +68 more
wiley   +1 more source

The Boston Psychiatric rehabilitation approach – evaluation of an implementation project in Sweden

open access: yes, 2012
Background: Despite the potential impact of psychiatric rehabilitation on wellbeing and health, there is a lack of research regarding the model called Psychiatric Rehabilitation Approach from Boston University.
Jormfeldt, Henrika,   +3 more
core   +2 more sources

Deep whole genome sequencing of epileptogenic brain lesions

open access: yesEpilepsia, EarlyView.
Abstract Objective Malformations of cortical development and low‐grade epilepsy‐associated tumors often cause drug‐resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information and may eventually support personalized treatment approaches.
Christian M. Boßelmann   +17 more
wiley   +1 more source

Repetitive clustered low‐voltage fast activity on intracranial electroencephalogram in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy: A candidate electroencephalographic biomarker study

open access: yesEpilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently recognized cause of drug‐resistant focal epilepsy. It is often magnetic resonance imaging‐negative or radiologically resembles focal cortical dysplasias, which makes recognition difficult and limits presurgical counseling ...
Vadym Gnatkovsky   +25 more
wiley   +1 more source

Late electroencephalographic seizure‐risk findings and restricted diffusion on magnetic resonance imaging as seizure‐burden markers associated with neurological deficits after status epilepticus in a remote or chronic cohort

open access: yesEpilepsia, EarlyView.
Abstract Objective To evaluate whether time‐dependent electroencephalographic (EEG) seizure risk findings and restricted diffusion on magnetic resonance imaging (MRI) are associated with neurological outcomes after status epilepticus (SE), beyond seizure duration. Methods This two‐center observational study included consecutive SE patients from 2017 to
Narumi Ohno   +12 more
wiley   +1 more source

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