Results 131 to 140 of about 2,253,089 (312)

Spiritual care at the end of life: whose job is it? [PDF]

, 2010
Interest in and recognition of the function of religious and spiritual coping in adjustment to serious illness has been growing. In particular, there has been increasing interest in the importance of understanding and valuing patients' individual ...
Psaila, Claudia, Watts, Jacqueline H.
core  

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Influencing factors of leakage in patients with urostomy and research progress of nursing interventions (尿路造口患者渗漏的影响因素及护理研究进展)

中西医结合护理
Leakage is a common complication in patients with urostomy after bladder cancer surgery, affecting patients' quality of life and psychological health. Recently, leakage in patients with urostomy has received widespread attention both at home and abroad ...
WANG Ping (王萍), WANG Jun (王俊), JI Xuebi (吉学碧), WANG Haifeng (王海峰)   +3 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions

Behavioral and Brain Functions
Background The Default Mode Network (DMN) is a central neural network, with recent evidence indicating that it is composed of functionally distinct sub-networks.
Maryana Daood, Noa Magal, Leehe Peled-Avron, Michael Nevat, Rachel Ben-Hayun, Judith Aharon-Peretz, Rachel Tomer, Roee Admon   +7 more
doaj   +1 more source

Social and Psychological Factors Associated with Health Care Transition for Young Adults Living with Sickle Cell Disease [PDF]

, 2019
Introduction: Due to advances in disease management, mortality rates in children with sickle cell disease (SCD) have decreased. However, mortality rates for young adults (YA) increased, and understanding of social and psychological factors is critical ...
Clayton-Jones, Dora L., Dalmida, Safiya George, Field, Joshua, Haglund, Kristin, Koch, Kathryn L., Leonard, Cynthia, Mager, Amy, Matthie, Nadine, Sawdy, Rachel, Treadwell, Marsha   +9 more
core   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

The person-based approach to intervention development: A scoping review of methods and applications

Digital Health
Background The person-based approach (PBA) has emerged as a prominent methodology guiding the development of digital and hybrid health behaviour change interventions over the last decade, and there is a salient need to understand its utilization ...
Lydia Holt, Sarah Denford, Hannah Bowers, Paula Kuberka, Ingrid Muller, Richard Amlôt, Lucy Yardley   +6 more
doaj   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Exploring the opinions and potential impact of unflavoured e-liquid on smoking cessation among people who smoke and smoking relapse among people who previously smoked and now use e-cigarettes: findings from a UK-based mixed methods study

Harm Reduction Journal
Background Although electronic cigarettes (e-cigarettes) appear to be effective in helping people who smoke to stop smoking, concerns about use of e-cigarettes among young people have led to restrictions on non-tobacco flavoured e-liquids in some ...
Jasmine N. Khouja, Maddy L. Dyer, Michelle A. Havill, Martin J. Dockrell, Marcus R. Munafò, Angela S. Attwood   +5 more
doaj   +1 more source