Results 81 to 90 of about 3,418 (250)

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

open access: yesAdvanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim   +2 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

open access: yesAdvanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang   +17 more
wiley   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong   +20 more
wiley   +1 more source

PENGARUH HARDINESS TERHADAP PSYCHOLOGICAL WELL-BEING PADA REMAJA KORBAN BULLYING [PDF]

open access: yes
Perilaku bullying masih sering kali terjadi pada remaja hingga menyebabkan berbagai permasalahan, khususnya kesejahteraan psikologis korban. Penelitian ini bertujuan untuk mengetahui pengaruh hardiness terhadap psychological well-being pada remaja korban
RIZKA PUTRI ANGGELINA, .
core  

Comparison of psychological hardiness in para swimmers with different training intensities [PDF]

open access: yes, 2020
Title: Comparison of psychological hardiness in para swimmers with different training intensities Objectives: The aim of the thesis is to compare psychological hardiness level among impaired para swimmers and non-sporting impaired individuals.
Míčková, Dominika
core  

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

open access: yesAdvanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim   +7 more
wiley   +1 more source

The role of Spiritual Experiences in the Psychological Hardiness of Nurses with the Mediation of Mindfulness

open access: yes, 2023
Introduction: Psychological toughness is described as one of the most important health potentials in theoretical and research bases, so the present study was conducted with the aim of investigating the mediating role of mindfulness in the relationship ...
Gholamreza Sanagouye Moharer   +2 more
core  

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