Results 171 to 180 of about 1,772,959 (342)

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Psychological Stress Exacerbates Inflammation of the Ileum via the Corticotropin-Releasing Hormone-Mast Cell Axis in a Mouse Model of Eosinophilic Enteritis [PDF]

, 2022
Atsushi Kanamori, Fumio Tanaka, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara   +10 more
openalex   +1 more source

Psychological stress measurement through voice output analysis [PDF]

Audio tape recordings of selected Skylab communications were processed by a psychological stress evaluator. Strip chart tracings were read blind and scores were assigned based on characteristics reported by the manufacturer to indicate psychological ...
Jenney, L. L., Older, H. J.
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Experts in traumatic stress are concerned about global impact of what is happening in U.S.

European Journal of Psychotraumatology
Trauma is a global issue and public health concern. Political decisions may directly impact rates of trauma exposure, be it individual trauma or mass disaster, and guide how we deal with the consequences of trauma.
Joan M. Cook, Debra L. Kaysen, Jackie June ter Heide, Cherie Armour, Marianne Skogbrott Birkeland, Sandra L. Bloom, John Briere, Eric Bui, Eve Carlson, Marylene Cloitre, Marie-Ève Daspe, Charles R. Figley, Julian D. Ford, Bonnie L. Green, Talya Greene, Rodrigo Gillibrand, Maj Hansen, Nathaniel G. Harnett, Irma M. Hein, Jinhee Hyun, Jana D. Javakhishvili, Debra Kaminer, Nancy Kassam-Adams, Karestan C. Koenen, Catrin Lewis, Alexander McFarlane, Alessandra Minelli, Candice Monson, Frank Neuner, Elana Newman, Angela Nickerson, Meaghan O’Donnell, Misari Oe, Matthew Price, Patricia Resick, Neil P. Roberts, Carolina Salgado, Ulrich Schnyder, Soraya Seedat, Antonia V. Seligowski, Marit Sijbrandij, Stuart Turner, Bessel van der Kolk, Miranda Olff   +43 more
doaj   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Psychological Stress and Cardiovascular Disease

Journal of the American College of Cardiology, 2008
There is an enormous amount of literature on psychological stress and cardiovascular disease. This report reviews conceptual issues in defining stress and then explores the ramifications of stress in terms of the effects of acute versus long-term stressors on cardiac functioning.
openaire   +2 more sources

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Role of Psychological Stress on Interferon-Gamma (IFN-γ) in Atopic Dermatitis

, 2018
Made Wardhana, Sudarmajaya Suryawati, Luh Made Mas Rusyati   +2 more
openalex   +1 more source