Results 101 to 110 of about 2,138,416 (357)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Predictors of Tuberculosis Treatment Behaviors Based on Social Stigma and Social Cognitive Theory in Southeastern Iran [PDF]

open access: yesIranian South Medical Journal
Background: Tuberculosis is the leading cause of death from a single infectious agent worldwide. This study aimed to investigate the predictors of tuberculosis treatment behaviors in patients in the Sistan, Iran. Materials and Methods: The study enrolled
Mojtaba Kondori   +4 more
doaj  

Explaining human interactions on the road by large-scale integration of computational psychological theory. [PDF]

open access: yesPNAS Nexus, 2023
Markkula G   +9 more
europepmc   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang   +6 more
wiley   +1 more source

Analysis of writing in personality disorders in prison population

open access: yesFrontiers in Psychiatry
Writing involves the activation of different processing modes than reading comprehension, and therefore the level of activation varies depending on the moment and the task.Objectivesto analyze the profiles in terms of the proposed coding from the PROESC ...
Lucas Muñoz-López   +3 more
doaj   +1 more source

Research Governance in Academia: Are there Alternatives to Academic Rankings? [PDF]

open access: yes
Peer reviews and rankings today are the backbone of research governance, but recently came under scrutiny. They take explicitly or implicitly agency theory as a theoretical basis. The emerging psychological economics opens a new perspective. As scholarly
Bruno S. Frey, Margit Osterloh
core  

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

open access: yesAdvanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger   +17 more
wiley   +1 more source

Why is Voting Habit-Forming: Evidence from Sweden [PDF]

open access: yes, 2010
For decades, scholars of electoral behavior have noted persistence in individuals' turnout decisions and hypothesized that such persistence is the result of habit.
Melton, James
core  

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

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