Advanced Science, EarlyView.Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox +9 more
wiley +1 more source
Housing Quality and Psychological Well-Being Among the Elderly Population [PDF]
, 2002 Gary W. Evans +2 more
openalex +1 more source
Is Retirement Depressing?: Labor Force Inactivity and Psychological Well-Being in Later Life [PDF]
This paper assesses how retirement - defined as permanent labor force non-participation in a man's mature years - affects psychological welfare. The raw correlation between retirement and well-being is negative. But this does not imply causation.
Kerwin Kofi Charles
core
Advanced Science, EarlyView.This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo +17 more
wiley +1 more source
Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes
Advanced Science, EarlyView.Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He +6 more
wiley +1 more source
The Awareness of Being Observed Changes the Patient’s Psychological Well-being in Anesthesia
, 2000 D. De Amici +3 more
openalex +1 more source
The prevalence of gastrointestinal symptoms in patients with chronic renal failure is increased and associated with impaired psychological general well-being [PDF]
, 2002 Hans Strid +5 more
openalex +1 more source
Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition
Advanced Science, EarlyView.This review summarizes the current landscape of big data and AI‐powered modeling in animal nutrition, covering techniques including intelligent data acquisition, data augmentation, explainable machine learning, heuristic algorithms, and life cycle assessment‐based sustainability evaluation.
Shuai Zhang +3 more
wiley +1 more source
Error prevention and well-being at work in western Europe and Russia. Psychological traditions and new trends de De Keyser et Leonova [PDF]
, 2002 Jacques Leplat
openalex +1 more source
Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation
Advanced Science, EarlyView.AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang +7 more
wiley +1 more source