Results 141 to 150 of about 10,392,229 (329)

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

Advanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman   +9 more
wiley   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

The Importance of Calibration in Clinical Psychology

Assessment (Odessa, Fla.), 2020
Oliver Lindhiem, Isaac T. Petersen, L. Mentch, E. Youngstrom   +3 more
semanticscholar   +1 more source

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source

Mud huts, haircuts and High School dropouts: The 3rd Annual Male Psychology Conference, University College London, June 2016. [PDF]

, 2016
This Special Issue of NMS comprises selected papers from the The 3rd Annual Male Psychology Conference, held at the University College London in June 2016, titled MUD HUTS, HAIRCUTS AND HIGH SCHOOL DROPOUTS.
Barry, JA
core  

Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition

Advanced Science, EarlyView.
This review summarizes the current landscape of big data and AI‐powered modeling in animal nutrition, covering techniques including intelligent data acquisition, data augmentation, explainable machine learning, heuristic algorithms, and life cycle assessment‐based sustainability evaluation.
Shuai Zhang, Changhua Lai, Jinbiao Zhao, Junjun Wang   +3 more
wiley   +1 more source

Psicología y Psicología Clínica : sobre árboles y ramas [PDF]

, 2008
En su evolución conceptual y profesional la psicología clínica es deudora, sin duda, de la psicología. Pero, al mismo tiempo, su propio objeto de estudio (los trastornos mentales y del comportamiento) no siempre ha sido bien visto ni aceptado por la ...
Belloch Fuster, Amparo
core   +1 more source

Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation

Advanced Science, EarlyView.
AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang, Qing Wang, Minghao Zhou, Jialu Liang, Lei You, Breton Asken, Xiaobo Zhou, Qianqian Song   +7 more
wiley   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

BROAD‐NESS Uncovers Dual‐Stream Mechanisms Underlying Predictive Coding in Auditory Memory Networks

Advanced Science, EarlyView.
BROADband Network Estimation via Source Space (BROAD‐NESS) is a flexible analytical pipeline for identifying large‐scale brain networks from event‐related, source‐reconstructed MEG data, with a focus on auditory predictive and memory processes. BROAD‐NESS integrates a suite of complementary tools, including PCA‐based decomposition, phase space, and ...
Leonardo Bonetti, Gemma Fernández‐Rubio, Mathias H. Andersen, Chiara Malvaso, Francesco Carlomagno, Claudia Testa, Peter Vuust, Morten L. Kringelbach, Mattia Rosso   +8 more
wiley   +1 more source