Results 151 to 160 of about 190,392 (258)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Creativity and its link to epilepsy

Epilepsia Open, EarlyView.
Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Chinese Version of the Life Change Adaptation Scale for Family Caregivers of Individuals of Stroke Survivors. [PDF]

J Multidiscip Healthc
Lin H, Zeng Y, Zhang X, Hu H, Ye Y, Huang S, Lin H.   +6 more
europepmc   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, EarlyView.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

Psychometric Validity of the CES-D Scale for Assessing Depressive Symptoms in University Students in Bogotá. Colombia. [PDF]

Int J Methods Psychiatr Res
Caro-Delgado AG, Mancilla VR, Medina-Parra J, Villalobos-Galvis FH.   +3 more
europepmc   +1 more source

Participation in the New Maudsley Model Workshops is Associated With Reductions in Caregiver Burden in Eating Disorders

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Caregivers of individuals with eating disorders (ED) frequently experience psychological distress, expressed emotion, and accommodation behaviours, contributing to caregiver burden. The New Maudsley Model (NMM) is a structured intervention designed to improve caregivers' emotional regulation, communication, and coping strategies ...
Cristiano Dani, Eleonora Rossi, Emanuele Cassioli, Giulia Selvi, Livio Tarchi, Francesco Rotella, Sandra Moretti, Maria Rita Troiani, Giulio D'Anna, Ilenia Giunti, Stefano Lucarelli, Janet Treasure, Valdo Ricca, Giovanni Castellini   +13 more
wiley   +1 more source

Development and psychometric evaluation of the Patient Safety Culture in Home Health Care Centers Instrument (PSCHCI): a sequential exploratory mixed-methods protocol in Iran. [PDF]

BMJ Open
Etebarian Khorasgani A, Ashghali Farahani M, Sharif-Nia H, Gholami M, Golestan F, Ghezeljeh TN.   +5 more
europepmc   +1 more source

Long‐Term Effectiveness of Inpatient and Day‐Hospital Treatment of Eating Disorders in Departments of Psychosomatic Medicine and Psychotherapy in Germany

European Eating Disorders Review, EarlyView.
ABSTRACT Background There is ample evidence on the efficacy of different therapeutic approaches in treating eating disorders. Yet, studies on the effectiveness of inpatient/day‐hospital treatment of eating disorders are rare. Method Data were retrieved from a naturalistic multi‐center effectiveness study of inpatient and day‐hospital treatment in ...
Magdalena Pape, Stephan Herpertz, Stephan Doering, Henrik Kessler, Martina de Zwaan, Almut Zeeck, Armin Hartmann, Tobias Hofmann, Matthias Rose, Katrin Imbierowicz, Franziska Geiser, Ilona Croy, Kerstin Weidner, Jörg Rademacher, Silke Michalek, Eva Morawa, Yesim Erim, Eva‐Maria Skoda, Martin Teufel, Stanislav Heinzmann, Claas Lahmann, Eva Milena Johanne Peters, Johannes Kruse, Dirk von Boetticher, Christoph Herrmann‐Lingen, Mariel Nöhre, Ulrike Dinger, Hans‐Christoph Friederich, Alexander Niecke, Christian Albus, Rüdiger Zwerenz, Manfred Beutel, Casper Roenneberg, Peter Henningsen, Barbara Stein, Christiane Waller, Karsten Hake, Carsten Spitzer, Andreas Stengel, Stephan Zipfel, Katja Weimer, Harald Gündel, Aram Kehyayan   +42 more
wiley   +1 more source

Psychometric Evaluation of the HIV Knowledge Questionnaire-18 in a Black Canadian Population. [PDF]

HIV AIDS (Auckl)
Nyambi A, Alvarez E, Anderson LN, Jackson-Best F, Tharao W, Etowa EB, Baidoobonso S, Owino M, Djiadeu P, Lawson DO, Mbuagbaw L.   +10 more
europepmc   +1 more source

The Importance of Considering Personal Recovery for Eating Disorders

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Definitions of recovery from eating disorders (EDs) have traditionally emphasised symptom reduction and functional restoration. However, growing research highlights the importance of integrating personal recovery, defined by self‐acceptance, autonomy, and psychological wellbeing.
Andrew Allen, Maddison Tunstall, Catherine Houlihan, Kay Pozzebon, Daniel B. Fassnacht, Kathina Ali   +5 more
wiley   +1 more source