Results 141 to 150 of about 111,302 (260)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

open access: yesEpilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha   +13 more
wiley   +1 more source

Creativity and its link to epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Psychometric Evaluation of the HIV Knowledge Questionnaire-18 in a Black Canadian Population. [PDF]

open access: yesHIV AIDS (Auckl)
Nyambi A   +10 more
europepmc   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

open access: yesEpilepsia Open, EarlyView.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro   +7 more
wiley   +1 more source

Participation in the New Maudsley Model Workshops is Associated With Reductions in Caregiver Burden in Eating Disorders

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Caregivers of individuals with eating disorders (ED) frequently experience psychological distress, expressed emotion, and accommodation behaviours, contributing to caregiver burden. The New Maudsley Model (NMM) is a structured intervention designed to improve caregivers' emotional regulation, communication, and coping strategies ...
Cristiano Dani   +13 more
wiley   +1 more source

Long‐Term Effectiveness of Inpatient and Day‐Hospital Treatment of Eating Disorders in Departments of Psychosomatic Medicine and Psychotherapy in Germany

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Background There is ample evidence on the efficacy of different therapeutic approaches in treating eating disorders. Yet, studies on the effectiveness of inpatient/day‐hospital treatment of eating disorders are rare. Method Data were retrieved from a naturalistic multi‐center effectiveness study of inpatient and day‐hospital treatment in ...
Magdalena Pape   +42 more
wiley   +1 more source

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