Results 151 to 160 of about 409,123 (298)

Jaspers: General Psychopathology [PDF]

, 1983
Myre Sim
openalex   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Differential effects of childhood maltreatment types and timing on psychopathology in formerly out-of-home placed young adults [PDF]

Maria Meier, Inga Schalinski, Cyril Boonmann, Nils Jenkel, Süheyla Seker, Delfine d’Huart, Jörg M. Fegert, Vera Clemens, Marc Schmid, David Bürgin   +9 more
openalex   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Associations Between Both Adaptive and Maladaptive Personality Constructs and Emotional Load and Content of Adult Dreams

Indian Journal of Psychological Medicine
Background: It seems that personality and dreams are relatively stable interwoven constructs that show many shared characteristics across cultures. The present study aimed to predict the emotional load and content of dreams using both original constructs
Saeid Komasi, Amin Nazari, Behrooz Faridmarandi, Mozhgan Saeidi, Mostafa Bahremand, Taherh Shadman, Atefeh Mirani, Parisa Nazarpour, Zhaleh Kiani, Ali Zakiei   +9 more
doaj   +1 more source

Earlier age at menarche as a transdiagnostic mechanism linking childhood trauma with multiple forms of psychopathology in adolescent girls

, 2019
Natalie L. Colich, Jonathan Platt, Katherine M. Keyes, Jennifer A. Sumner, Nicholas B. Allen, Katie A. McLaughlin   +5 more
openalex   +2 more sources

Merleau-Ponty and the Foundations of Psychopathology [PDF]

, 2019
Fernandez, Anthony Vincent
core   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Conics, (q+1)-Arcs, Pencil Concept of Time and Psychopathology [PDF]

, 2003
Метод Санига
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Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source