Results 71 to 80 of about 389,527 (304)

On the transience or stability of subthreshold psychopathology

Scientific Reports, 2021
Symptoms of psychopathology lie on a continuum ranging from mental health to psychiatric disorders. Although much research has focused on progression along this continuum, for most individuals, subthreshold symptoms do not escalate into full-blown ...
Marieke J. Schreuder, Johanna T. W. Wigman, Robin N. Groen, Marieke Wichers, Catharina A. Hartman   +4 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A clinical heritage of empirical research. In memory of Jeremy Safran [PDF]

, 2019
This is Part II of a special issue, Research in Psychotherapy: Psychopathology, Process and Outcome, dedicated in memory of our colleague Jeremy Safran (Part I was published in April 2019).
Gentile, Daniela, Lingiardi, Vittorio
core   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Maternal Burnout Syndrome: Contextual and Psychological Associated Factors

Frontiers in Psychology, 2018
Background: Becoming a parent is one of the most significant experiences in a woman’s life. Including substantial and long-lasting mental, social, and physical charge, the parenting experience may also be a potentially stressful and overwhelming task ...
Astrid Lebert-Charron, Géraldine Dorard, Emilie Boujut, Emilie Boujut, Jaqueline Wendland   +4 more
doaj   +1 more source

Situated Psychopathology

Integrative Psychological and Behavioral Science
Abstract This article seeks to formulate a situated approach to mental disorder that overcomes some of the problems of contemporary diagnostic psychiatry. A framework is needed that aims to integrate neuroscientific knowledge about the brain and other aspects of the person with knowledge about the environment.
openaire   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. [PDF]

, 2019
Some people are more willing to make immediate, risky, or costly reward-focused choices than others, which has been hypothesized to be associated with individual differences in dopamine (DA) function.
Castrellon, Jaime J, Cowan, Ronald L, Crawford, Jennifer L, Dang, Linh C, Hsu, Ming, Samanez-Larkin, Gregory R, Seaman, Kendra L, Smith, Christopher T, Young, Jacob S, Zald, David H   +9 more
core   +1 more source

The role of attachment anxiety in parent’s attentional processing of their child’s face : an eye tracking study [PDF]

, 2016
Although mother's attention to offspring is deemed important to support their offspring's secure attachment development, little research tested this association.
Bosmans, Guy, Braet, Caroline, Müller, Sven, van de Brande, Sofie, Vandevivere, Eva   +4 more
core   +2 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source