Results 81 to 90 of about 2,467,646 (296)

Positive Affect is Associated with Better Physical Function in Early Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤ 24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir, Jing Song, Lutfiyya N. Muhammad, Wendy Marder, Kevin Deane, Clifton Bingham, Lisa A. Mandl, Robert Edwards, Judith T. Moskowitz, Yvonne C. Lee   +9 more
wiley   +1 more source

Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical trial [PDF]

, 2016
Although survival rates in childhood cancer have improved, prevention and reduction of late effects remain important. This study evaluates the effects of a combined physical exercise and psychosocial intervention on health-related quality of life (HrQoL)
Merks, Johannes H., Veening, MA, Eline van Dulmen‐den Broeder, Streng, Isabelle, van Dijk-Lokkart, EM, van Dulmen-den Broeder, Eline, van Dulmen-den Broeder, E, van den Heuvel-Eibrink, Marry M., Bierings, M, Tim Takken, Grootenhuis, MA, Marc Bierings, Takken, T, Huisman, J, Elisabeth M. van Dijk‐Lokkart, Johannes H. Merks, Gertjan J. L. Kaspers, Jaap Huisman, Grootenhuis, Martha A., Bierings, Marc, Kaspers, Gertjan J. L., Braam, Katja I., Streng, Isabelle C., Isabelle C. Streng, Merks, JH, Martha A. Grootenhuis, Veening, Margreet A., Huisman, Jaap, Braam, KI, Van den Heuvel - Eibrink, Marry, Margreet A. Veening, Takken, Tim, Katja I. Braam, Kaspers, GJL, Kaspers, Gertjan J L, Marry M. van den Heuvel‐Eibrink, van Dijk-Lokkart, Elisabeth M.   +36 more
core   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

Psychosocial therapy for Parkinson's-related dementia: intervention development [PDF]

, 2017
Sheree A McCormick,1,2,* Kathryn R McDonald,1,2,* Sabina Vatter,1–3 Vasiliki Orgeta,4 Ellen Poliakoff,1,2 Sarah J Smith,5 Iracema Leroi1–3 1Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK ...
Sarah Smith, Vatter, Sabina, McCormick, SA, McDonald, KR, Leroi, Iracema, Vatter S, Orgeta V, Smith, SJ, Leroi I, Poliakoff, Ellen; id_orcid, Ellen Poliakoff, McCormick SA, Mccormick, Sheree, Leroi, I, Mcdonald, Kathryn, Poliakoff E, Vasiliki Orgeta, McDonald KR, Kathryn McDonald, Orgeta, Vasiliki, Sheree A McCormick, Smith, Sarah, Poliakoff, E, Sabina Vatter, Orgeta, V, Smith SJ, Iracema Leroi, Vatter, S   +27 more
core   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Psychosocial risk factors in home and community settings and their associations with population health and health inequalities: a systematic meta-review [PDF]

, 2008
<p><b>Background:</b> The effects of psychosocial risk factors on population health and health inequalities has featured prominently in epidemiological research literature as well as public health policy strategies.
Petticrew, Mark, Sian Thomas, Egan Matt, Egan, Matt, Matt Egan, Thomas, S., Thomas Sian, Tannahill, Carol, Petticrew Mark, Mark Petticrew, Tannahill Carol, Carol Tannahill, Thomas, Sian, Tannahill, C., Petticrew, M., Egan, M.   +15 more
core   +2 more sources

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Global Burden and Temporal Trends of Early‐Onset Tracheal, Bronchial, and Lung Cancer: An Analysis of GLOBOCAN 2022 and GBD 2023 Data

Advanced Science, EarlyView.
This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian, Weihao Zhang, Yao Lu, Bruce F. O'Hara, Jingjing Hu, Hanqi Feng, Jing Di, Lei Zhang, Xueying Yang   +8 more
wiley   +1 more source