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Protecting PTEN in the Nucleus
Cancer Discovery, 2017Abstract A recent study shows that the transport receptor Importin-11 relocates PTEN, a tumor suppressor, to the nucleus, preventing its degradation in the cytoplasm. Mice lacking Importin-11 are prone to lung cancers, and its absence in human prostate and lung tumors signals a poorer prognosis.
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Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
Cancer Cell, 2019Di Zhao, Alan Wang, Andrew Chang
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The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Nature Reviews Molecular Cell Biology, 2018Yu-Ru Lee +2 more
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Mechanisms of PTEN loss in cancer: It’s all about diversity
Seminars in Cancer Biology, 2019Nick R. Leslie, Virginia Alvarez Garcia
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