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Screening and Management of PTLD
Transplantation, 2023Posttransplant lymphoproliferative disorder (PTLD) represents a heterogeneous group of lymphoproliferative diseases occurring in the setting of immunosuppression following hematopoietic stem cells transplant and solid organ transplantation. Despite its overall low incidence, PTLD is a serious complication following transplantation, with a mortality ...
Lorenzo, Zaffiri, Eileen T, Chambers
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Das pädiatrische PTLD-Register (Ped-PTLD-Register)
Der Nephrologe, 2009Lymphoproliferative Erkrankungen (PTLD) sind seltene, doch schwere Komplikationen der immunsuppressiven Therapie nach Organtransplantation. Sie entstehen meist auf dem Boden einer gestorten Immunantwort gegenuber Epstein-Barr-Virus (EBV). Im Kindesalter werden pro Jahr in Deutschland etwa 15–20 Kinder mit PTLD diagnostiziert.
B. Maecker-Kolhoff, C. Klein
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PTLD after Lung Transplantation
2021The specter of post-transplant lymphoproliferative disorder (PTLD) hangs over the lung transplant population like the legendary sword of Damocles, as an ever-present danger which is even more apparent in the pediatric population. The major risk factor, of course, is primary Epstein-Barr virus infection usually transmitted via a seropositive donor into ...
Allan R. Glanville, Gary Visner
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PTLD After Heart Transplantation
2021PTLD in adult and childhood heart transplant recipients remains poorly understood but is associated with double the mortality compared to recipients without PTLD. PTLD makes up the minority of malignancies (1%) in adults post-heart transplant, and, other than younger age, there is a clear paucity of data in the literature regarding risk factors for ...
Anne I. Dipchand, Michael McDonald
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Leukemia & Lymphoma, 2020
Classic Hodgkin lymphoma (CHL) is the rarest post-transplant lymphoproliferative disorder (PTLD) subtype. Few cases of patients with metachronous discordant PTLD episodes including CHL-PTLD have been reported, but the incidence of and risk factors for this phenomenon are unknown.
Ryan J. Stubbins +6 more
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Classic Hodgkin lymphoma (CHL) is the rarest post-transplant lymphoproliferative disorder (PTLD) subtype. Few cases of patients with metachronous discordant PTLD episodes including CHL-PTLD have been reported, but the incidence of and risk factors for this phenomenon are unknown.
Ryan J. Stubbins +6 more
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2021
No therapies for PTLD after solid organ transplantation are based on data from randomized clinical trials, but available phase II trial data help guide therapeutic decision making. Reduction or cessation of immunosuppression is performed at the time of diagnosis in almost all patients.
Ralf Ulrich Trappe, Steven A. Webber
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No therapies for PTLD after solid organ transplantation are based on data from randomized clinical trials, but available phase II trial data help guide therapeutic decision making. Reduction or cessation of immunosuppression is performed at the time of diagnosis in almost all patients.
Ralf Ulrich Trappe, Steven A. Webber
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Isolated pleural PTLD after cardiac transplantation
Cardiovascular Pathology, 2002PREAMBLE: Epstein-Barr virus infection (EBV) and immunosuppression promote emergence of posttransplant lymphoproliferative disorders (PTLD) in patients undergoing organ transplantation.We report a case of PTLD confined to the pleura.The patient was a 62-year-old male who had undergone cardiac transplant in 1993 for ischemic heart disease.
Manisha, Lamba +4 more
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PTLD in Intestinal Transplant Recipients
2021Post-transplant lymphoproliferative disorder (PTLD), a lethal disease, is a direct consequence of modulation of recipient’s immune system by immunosuppression. Intestinal transplant recipients are at particular risk given the intensity of necessary immunosuppression and the volume of transplanted lymphoid tissue.
Ajai Khanna, George V. Mazariegos
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T‐cell PTLD presenting as acalculous cholecystitis
Pediatric Transplantation, 2008Abstract: We report a five‐yr‐old child, presenting three yr after heart transplant with acalculous cholecystitis. Histology revealed EBV negative T‐cell PTLD. The disease involved the gallbladder, liver, lungs, and mesenteric lymph nodes. He was treated with chemotherapy, went into remission, but relapsed after 11 months and died.
Tamir, Miloh +8 more
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2010
Poor prognostic factors in the traditional non-Hodgkin's lymphomas (NHL), such as poor performance status, multifocal disease, and increased age, are also poor prognostic factors in posttransplant lymphoproliferative disorders (PTLD). Rituximab has proven efficacy in CD-20 positive PTLD and has altered the management and prognosis of this disease.
Tapan Maniar, Donald Tsai
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Poor prognostic factors in the traditional non-Hodgkin's lymphomas (NHL), such as poor performance status, multifocal disease, and increased age, are also poor prognostic factors in posttransplant lymphoproliferative disorders (PTLD). Rituximab has proven efficacy in CD-20 positive PTLD and has altered the management and prognosis of this disease.
Tapan Maniar, Donald Tsai
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