Results 81 to 90 of about 111,177 (248)

Knocking down low molecular weight protein tyrosine phosphatase (LMW-PTP) reverts chemoresistance through inactivation of Src and Bcr-Abl proteins.

PLoS ONE, 2012
The development of multidrug resistance (MDR) limits the efficacy of continuous chemotherapeutic treatment in chronic myelogenous leukemia (CML). Low molecular weight protein tyrosine phosphatase (LMW-PTP) is up-regulated in several cancers and has been ...
Paula A Ferreira, Roberta R Ruela-de-Sousa, Karla C S Queiroz, Ana Carolina S Souza, Renato Milani, Ronaldo Aloise Pilli, Maikel P Peppelenbosch, Jeroen den Hertog, Carmen V Ferreira   +8 more
doaj   +1 more source

Data‐Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño, Shekeeb S. Mohammad, Rajeshwar Reddy Angiti, Velda Han, Michel Tchan, Russell C. Dale, Victor S.C. Fung   +6 more
wiley   +1 more source

Beyond Bioenergetics: Moonlighting Functions of F1FO‐ATPase From ATP Synthesis to an ATP‐Wasting Death Switch

Medicinal Research Reviews, EarlyView.
ABSTRACT Mitochondrial F1FO‐ATPase is classically viewed as the “splendid” rotary nanomachine that sustains life by converting the proton‐motive force (pmf) into ATP. Yet this same complex can adopt a second, context‐dependent function that links bioenergetics to cell fate.
Salvatore Nesci
wiley   +1 more source

The clinical usefulness of three depression screens for adolescents in India: A need in primary-care settings

Journal of Family Medicine and Primary Care, 2019
Introduction: Adolescent Depression (AD) although is widely prevalent and is a prioritized disorder, it is under-diagnosed and under reported in primary-care.
Sushila Russell, Shonima A Viswanathan, SatyaRaj Shankar, Priya M Mammen, Paul S S. Russell   +4 more
doaj   +1 more source

The magnitude and economic replacement value of wild meat obtained from ‘recreational’ big game hunting in the United States

People and Nature, EarlyView.
Abstract Meat production has notable benefits for food security, nutrition and various production economies, but has elicited substantial negative environmental impacts. Recreational hunting provides an alternative to agricultural meat production for over 24 million hunters worldwide.
Shane P. Mahoney, Richard D. Honor
wiley   +1 more source

Dephosphorylated EphA2 in LMW-PTP KDs and MDA-MB-435.

, 2013
Error bars represent standard deviation (n=3). p > 0.05 for all comparisons. KD NT – scramble sequences siRNA (control); KD LMW-PTP – total LMW-PTP knockdown; KD LMW-PTP slow – LMW-PTP slow isoform knockdown.
Luis Costa (4762266), Manuel Bicho (463812), Constança Coelho (463813), Irina Alho (413134)   +3 more
core   +1 more source

Distinct Conformational Switches Control WPD‐Loop Dynamics Across Protein Tyrosine Phosphatase Subfamilies

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein Tyrosine Phosphatases (PTPs) regulate cellular signaling by balancing phosphotyrosine levels through a conserved WPD‐loop that switches between open (inactive) and closed (active) conformations. While this conformational change is crucial for catalysis, the structural factors governing this motion remain poorly understood.
Colin L. Welsh, Lalima K. Madan
wiley   +1 more source

Identification of a Filamin Docking Site on PTP-PEST [PDF]

, 2006
PTP-PEST is a cytoplasmic protein-tyrosine phosphatase (PTP) implicated in the regulation of biological processes such as cell motility, cytokinesis, focal adhesion disassembly, and lymphocyte activation.
Playford, Martin P., Schaller, Michael D., Lyons, Patrick D., Sastry, Sarita K.   +3 more
core   +1 more source

Interhospital Transfer Patients With Necrotizing Soft Tissue Infections: An Evaluation of the Role for Pretransport Operation

World Journal of Surgery, EarlyView.
Among transferred NSTI patients, mortality did not differ between PRE and the remainder of the cohort. PRE patients had longer hospital stays and higher healthcare charges, possibly due to worse physiology or more complex wounds. ABSTRACT Background Early debridement is the cornerstone of treatment for necrotizing soft tissue infections (NSTI), but ...
Hans V. Strobl, Diane N. Haddad, Renee Bicaba, Renee I. Tristano, Phillip M. Dowzicky, Abid D. Khan, Timothy P. Plackett, Justin S. Hatchimonji   +7 more
wiley   +1 more source

Measurement module with PTP synchronization

Tato diplomová práce se zabývá časovou synchronizací přesných měřicích systémů. Práce zkoumá různé protokoly pro časovou synchronizaci a především se zaměřuje na využití Precision Time Protocol (PTP).
Brabenec, Josef
core   +1 more source