Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Patient and public involvement in health and social care doctoral research: recommendations co-produced by doctoral researchers, public contributors, and a public involvement coordinator. [PDF]
Res Involv EngagemCurry J +4 more
europepmc +1 more source
Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li +10 more
wiley +1 more source
Opportunities to improve public health in China
The Lancet Public HealthThe Lancet Public Health
doaj +1 more source
Exploring staff and students' understanding and experience of Public and Patient Involvement (PPI) in an Irish University. [PDF]
Res Involv EngagemKavanagh B +7 more
europepmc +1 more source
Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli +5 more
wiley +1 more source
Housing: a determinant of health and equity
The Lancet Public HealthThe Lancet Public Health
doaj +1 more source
Experiences of professional public health advocacy in the UK health and social care system: a qualitative survey study [using the Theoretical Domains Framework]. [PDF]
J Public Health (Oxf)Marynissen K, Pabary A, Moffat M.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
A public health approach to suicide prevention
The Lancet Public HealthThe Lancet Public Health
doaj +1 more source