Results 41 to 50 of about 12,844,998 (309)

Recovery Time and Predictors among Under-Five Children with Severe Acute Malnutrition Admitted to Outpatient Management at Dodota District of Oromia, Ethiopia [PDF]

International Journal of Nutrition Sciences
Background: Severe acute malnutrition (SAM) is one of the common childhood problems worldwide endangering the lives of 17 million (2.5%) children under five years old. It is also highly prevalent among Ethiopian under-five-year children (7%).
Gezzu Lemma, Hailu Fekadu, Amde Eshete, Derese Teshome   +3 more
doaj   +1 more source

Business innovations and their key factors: public funding, human capital, and their relationships with the industrial environment

Tendencias, 2021
Considering that innovation plays a relevant role in the current business environment, this article investigates the effect of public funding invested in science, technology, and innovation on obtaining innovative results in industrial companies in ...
Martha Liliana Torres-Barreto, Yojan Sebastián Medina Charry, Mileidy Alvarez-Melgarejo   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Pembrolizumab-induced fulminant type 1 diabetes with C-peptide persistence at first referral

Endocrinology, Diabetes & Metabolism Case Reports, 2020
A 72-year-old man with no history of diabetes was referred to our department due to hyperglycemia during pembrolizumab treatment for non-small-cell lung carcinoma.
Kazuhisa Kusuki, Saya Suzuki, Yuzo Mizuno   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Utility of albumin-adjusted calcium and calcium‒phosphorus difference in screening for primary hyperparathyroidism

BMC Endocrine Disorders
Purpose Primary hyperparathyroidism (PHPT) is often asymptomatic but increases the risk of osteoporosis, fractures, and cardiovascular mortality. We evaluated the effectiveness of albumin-adjusted calcium (aCa) formulas and the calcium–phosphorus (Ca–P ...
Ataru Okumura, Tatsuya Bando, Ryosei Ashida, Mitsuhiro Kuno, Naoki Tamaki, Toshihiro Mizuguchi, Issei Uchida, Hiroshi Arima   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Recurrent cellulitis associated with lymphoedema in Noonan syndrome: case reports with RIT1 variants and literature review

Human Genome Variation
Noonan syndrome (NS) is a RASopathy, a disorder caused by genetic alterations involving the Ras/mitogen-activated protein kinase pathway. It causes characteristic clinical manifestations, including facial dysmorphism and congenital cardiac defects ...
Yuki Kobayashi, Takeya Adachi, Umi Tahara, Moemi Tanaka, Hiroki Arakawa, Yohei Funatsu, Kazunori Moritani, Mamiko Yamada, Kenjiro Kosaki, Toyoko Inazumi   +9 more
doaj   +1 more source

Correlation between carbapenem susceptibility in Pseudomonas aeruginosa and modified antibiotic heterogeneity index: a multicenter observational study using a surveillance platform

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: This study focused on exploring the relationship between antimicrobial use indicators, including the modified antibiotic heterogeneity index (mAHI), and the carbapenem susceptibility in Pseudomonas aeruginosa.
Keisuke Sawada, Takaaki Kato, Shuji Kono, Hiromi Kaneko, Hayato Nakano, Shinobu Inada, Tatsuya Isogawa, Tadahiro Shimizu, Namiko Takahashi, Haruki Takano, Hiroaki Chiba, Makoto Sugimoto, Ryo Inose, Yuichi Muraki, Hideki Araoka   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source