Results 201 to 210 of about 1,919,659 (338)

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Assessing and bridging the gap in vaccinology education: insights from Romanian medical universities. [PDF]

BMC Med Educ
Neculau AE, Șovăilă S, Dumitra G, Pistol A, Rogozea L, Lăcătuș A.   +5 more
europepmc   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

A study on the construction of a nurse refresher training system in traditional Chinese medicine hospitals using the Delphi method. [PDF]

Front Public Health
An Y, Xu H, Ma Q, Wang X, Ding Y, Yang R, Yang S.   +6 more
europepmc   +1 more source

Knowledge Exchange Framework: Clustering and narrative templates: Report detailing the clustering arrangements and providing narrative statement templates for the first iteration of the Knowledge Exchange Framework [PDF]

, 2020

core  

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Correlation between structural determinants and universal health coverage in 2010 and 2019: An analysis of the global burden of disease study. [PDF]

PLOS Glob Public Health
do Amaral Junior OL, Braccini Fagundes ML, Hugo FN, Kassebaum NJ, do Amaral Giordani JM.   +4 more
europepmc   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Instructors' Views on and Experiences with <i>Last Aid Courses</i> as a Means for Public Palliative Care Education-A Longitudinal Mixed-Methods Study. [PDF]

Int J Environ Res Public Health
Bollig G, Müller-Koch S, Zelko E.
europepmc   +1 more source

Safeguarding the Public: Historical Aspects of Medicinal Drug Control edited by John B. Blake, Baltimore and London, Johns Hopkins Press, 1970, pp. xi, 200, £3 75. [PDF]

Medical History, 1972
openaire   +1 more source