Results 231 to 240 of about 1,993,468 (307)

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

Advanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen, Chunbin Gu, Shuoyan Tan, Xiaorui Wang, Yuquan Li, Mutian He, Ruiqiang Lu, Shijia Sun, Chang‐Yu Hsieh, Xiaojun Yao, Huanxiang Liu, Pheng‐Ann Heng   +11 more
wiley   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

The 10-year NHS plan needs a workforce equity foundation. [PDF]

J R Soc Med
Powell RA, Nayar V, Al-Haddad M, Kar P, Sathyamoorthy G, Rao M.   +5 more
europepmc   +1 more source

Mixing methods: How listening to researchers, healthcare workers, and community members can improve the design of studies testing medical innovations for Neglected Tropical Diseases. [PDF]

PLoS Negl Trop Dis
Erber AC, Ablordey A, Addissie A, Ahortor EK, Burtscher D, Mukooza EM, Creswell R, Lambert B, Olliaro PL.   +8 more
europepmc   +1 more source

Machine Learning Applications in Population and Public Health: Guidelines for Development, Testing, and Implementation.

JMIR Public Health Surveill
Pinto AD, Birdi S, Durant S, Rabet R, Parekh R, Ali S, Buckeridge D, Ghassemi M, Gibson J, John-Baptiste A, Macklin J, McCradden MD, McKenzie K, Naraei P, Owusu-Bempah A, Rosella LC, Shaw J, Upshur R, Mishra S.   +18 more
europepmc   +1 more source

Educational escape game in emergency medicine: what criteria are needed to increase satisfaction: a focus group study. [PDF]

BMC Med Educ
Freyer AC, Bosio A, Laudren G, Goetz C, Pelaccia T, Abensur Vuillaume L.   +5 more
europepmc   +1 more source