Results 51 to 60 of about 1,919,659 (338)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

COOPERATION IN THE FIELD OF ECONOMICS, OF SCIENCE AND MEDICINE IN EUROPE [PDF]

Economy and Sociology, 2015
The issue of medical cooperation raises many questions current and controversial, which are the focus of interest in socio-political and legal, such as debates on instruments to combat the high costs, the public health system, legislation aimed at ...
Norina-Consuela FORNA, Doriana FORNA AGOP, Alexandru GRIBINCEA   +2 more
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Un savoir thérapeutique hybride et mobile

Revue d'anthropologie des connaissances, 2011
The issue of innovations in TCM (zhongyi) – the Chinese medicine integrated in the public health system promoted by the post-1949 Chinese government, is approached through the case-study of the ongoing biomedicalisation of TCM research and the use of ...
Évelyne Micollier
doaj   +1 more source

Current Issues in Sport Science

Current Issues in Sport Science, 2022
CISS welcomes and encourages articles addressing a broad range of topics across sport science which include but is not limited to genetic, biological, physical, physiological, psychological, pedagogical, sociological, environmental, policy among other ...
Claudio Nigg, Markus Tilp, Günter Amesberger, Carol Ewing Garber, Thomas Finkenzeller, Martin Keller, Christine Pellegrini, Sebastian Ruin, Thorsten Stein, Ansgar Thiel, Mireille van Poppel, Sabine Würth   +11 more
doaj   +1 more source

Expert consensus regarding drivers of antimicrobial stewardship in companion animal veterinary practice: a Delphi study [PDF]

, 2018
Antimicrobial resistance (AMR) is a global challenge facing both human and animal healthcare professionals; an effective response to this threat requires a ‘One-Health’ approach to antimicrobial stewardship (AMS) to preserve important antibiotics for ...
Cinquepalmi, Coe, Damborg, Hughes, Ness, Pomba   +5 more
core   +3 more sources

Methodological and terminological issues in animal-assisted interventions: An umbrella review of systematic reviews [PDF]

, 2020
Recently, animal-assisted interventions (AAIs), which are defined as psychological, educational, and rehabilitation support activities, have become widespread in different contexts.
Amato, A., Carratu, R. C., Dice, F., Fioretti, A., Menna, L. F., Santaniello, A.   +5 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Issues potentially affecting quality of life arising from long-term medicines use: a qualitative study [PDF]

, 2013
Background Polypharmacy is increasing and managing large number of medicines may create a burden for patients. Many patients have negative views of medicines and their use can adversely affect quality of life.
A Alic, A Bowling, A Thompson, B Guthrie, BA Golomb, C Anderson, C Fox, C Salisbury, CA Anderson, CE Eades, DC Berry, DT Eton, DT Eton, F Stevenson, J Krska, J Krska, J Krska, J Krska, J Krska, JW Saultz, K Cox, L Ong, M May, MA Boustani, MA Hassali, MG Duerden, MJ Atkinson, N Britten, N Mead, P Pound, PA Rochon, R Adler, R Horne, RA Elliott, RA Elliott, S Kripalani, S Williams, SE Campbell, SN Weingart, T Kairuz, V Nunes   +40 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source