Results 71 to 80 of about 4,570,917 (333)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Inteligencia Artificial en Medicina y Salud: revisión y clasificación de las aplicaciones actuales y del futuro cercano y su impacto ético y social [PDF]

, 2020
This paper provides an overview of the current and near-future applications of Artificial Intelligence (AI) in Medicine and Health Care and presents a classification according to their ethical and societal aspects, potential benefits and pitfalls, and ...
Capitan-Morales, Luis-Cristobal, Dorado, Manuel E., Fernández-Lizaranzu, Isabel, Guerrero-Claro, Manuel, Gómez, Emilia, Gómez-González, Emilio, Izquierdo Ayuso, Guillermo, Mayorga-Buiza, M.J., Márquez Rivas, Javier, Relimpio-López, María Isabel   +9 more
core  

Exploration and Practice of the “One Combination， Two Highlights， Three Combinations， Four in One” Innovative Talents Training Mode in Forensic Medicine

Fayixue Zazhi, 2023
Talent is one of the basic and strategic supports for building a modern socialist country in all aspects. Since the 1980s, the establishment of forensic medicine major and the cultivation of innovative talents in forensic medicine have become hot topics ...
YAN Jiang-wei, SUN Jun-hong, WANG Hong-xing, WEI Zhi-wen, GUO Xiang-jie, LI Ji, GAO Cai-rong, ZHANG Geng-qian, LIANG Xin-hua, ZHANG Qiang-qiang, WANG Hong-wei, LI Si-jin, WANG Ying-yuan, YUN Ke-ming   +13 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Electronic Logistic Management Information System in Public Health Facilities and Its Implications for the Medicine Supply Chain in Singida District Council, Tanzania

Pharmacy
The effective management of the medicine supply chain is crucial for ensuring the availability of essential medicines and supplies in public health facilities.
Anwar Milulu, Stanley Mwita, Namanya Basinda   +2 more
doaj   +1 more source

Development of Intelligent Response to Public Health Emergencies

中国工程科学, 2021
An informationtized, digitalized, and intelligent emergency response mode is currently required in China to address the weaknesses and low efficiency in public health emergency management in the aspects of quick response mechanism, multi-department ...
Yao Jianyi , Jin Yaling , Tang Xiaoyong , Wu Jiabing , Hou Sai , Liu Xiaoqing , Zhang Tianchen , Song Tie , Xiao Jianpeng , Liu Jianjun   +9 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Evaluation of community level interventions to address social and structural determinants of health: a cluster randomised controlled trial [PDF]

, 2009
Background: In London and the rest of the UK, diseases associated with poor diet, inadequate physical activity and mental illness account for a large proportion of area based health inequality.
Clow, Angela, Clow, Angela, Draper, Alizon, Draper, Alizon, Hayes, Richard, Hayes, Richard, Lock, Karen, Lock, Karen, Lynch, Rebecca, Lynch, Rebecca, Moore, D., Moore, D., Petticrew, Mark, Petticrew, Mark, Renton, A., Renton, A., Schmidt, Elena, Schmidt, Elena, Wall, Martin, Wall, Martin   +19 more
core   +5 more sources

Biomedical informatics and translational medicine

Journal of Translational Medicine, 2010
Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine.
Sarkar Indra
doaj   +1 more source