Results 81 to 90 of about 4,570,917 (333)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Быть здоровым или иметь здоровье? Сообщение II. Общественная медицина и её экономические основы [PDF]

, 2013
Рассматриваются этико–деонтологические и экономические вопросы взаимоотношений врача и пациента в общественной медицине и других моделях медицины индустриального общества.
Зайчик, А.Ш., Чурилов, Л.П., Чурилов, Р.Л.   +2 more
core  

Some considerations concerning the challenge of incorporating social variables into epidemiological models of infectious disease transmission [PDF]

, 2015
Incorporation of ‘social’ variables into epidemiological models remains a challenge. Too much detail and models cease to be useful; too little and the very notion of infection —a highly social process in human populations—may be considered with little ...
Anderson R. M., Anderson R. M., Aunger R., Banaji M., Barnett T., Barnett T., Denton D., Durkheim É., Durkheim É., Fishbein M., Grimm V., Guillaume Fournié, Janet Seeley, Leach M., Levin S., Mansnerus E., Parkhurst J. O., Portas M., Rahamat-Langendoen J. C., Rubincam C., Sugunan A. P., Sunetra Gupta, Tony Barnett, Weber M., Weber M.   +24 more
core   +3 more sources

Deep Learning for Automated Classification of Tuberculosis-Related Chest X-Ray: Dataset Specificity Limits Diagnostic Performance Generalizability [PDF]

arXiv, 2018
Machine learning has been an emerging tool for various aspects of infectious diseases including tuberculosis surveillance and detection. However, WHO provided no recommendations on using computer-aided tuberculosis detection software because of the small number of studies, methodological limitations, and limited generalizability of the findings.
arxiv  

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

An overview of extended-spectrum beta-lactamases in veterinary medicine and their public health consequences

Journal of Infection in Developing Countries, 2014
Serious human and animal infections caused by bacteria are usually treated with beta-lactams. Extended-spectrum beta-lactamases (ESBLs) constitute the most clinically and economically important enzymes that are able to hydrolyze and inactivate beta ...
Diego Borin Nóbrega, Marcelo Brocchi
doaj   +1 more source

Report of the Medical Image De-Identification (MIDI) Task Group -- Best Practices and Recommendations [PDF]

arXiv, 2023
This report addresses the technical aspects of de-identification of medical images of human subjects and biospecimens, such that re-identification risk of ethical, moral, and legal concern is sufficiently reduced to allow unrestricted public sharing for any purpose, regardless of the jurisdiction of the source and distribution sites. All medical images,
arxiv  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Samples and data accessibility in research biobanks. An explorative survey [PDF]

, 2016
Biobanks, which contain human biological samples and/or data, provide a crucial contribution to the progress of biomedical research. However, the effective and efficient use of biobank resources depends on their accessibility.
Anagnostou, Paolo, Bisol, Giovanni Destro, Capocasa, Marco, D'Abramo, Flavio, Dominici, Valentina, Matteucci, Giulia, Rufo, Fabrizio   +6 more
core   +2 more sources